Multi-step reaction with 7 steps
1.1: copper; copper(I) oxide; potassium carbonate / 2-ethoxy-ethanol / 70 h / 138 °C / 760.05 Torr / Inert atmosphere
1.2: 1 h / 760.05 Torr / pH < 2 / Inert atmosphere
2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C / 760.05 Torr / Inert atmosphere
3.1: tetrahydrofuran / 0 - 20 °C / 760.05 Torr / Inert atmosphere
4.1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere
5.1: potassium carbonate / methanol / 3 h / 760.05 Torr / Inert atmosphere; Reflux
5.2: 2 h / 70 °C / 760.05 Torr / Inert atmosphere
6.1: platinum(IV) oxide; hydrogen; hydrogenchloride / dichloromethane; 1,4-dioxane; ethyl acetate / 3 h / 20 °C / 760.05 Torr / Inert atmosphere
7.1: bromotripyrrolidin-1-ylphosphonium; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / 760.05 Torr / Inert atmosphere
With
copper(I) oxide; hydrogenchloride; platinum(IV) oxide; hydrogen; copper; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bromotripyrrolidin-1-ylphosphonium;
In
tetrahydrofuran; 1,4-dioxane; methanol; 2-ethoxy-ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;