N-(2-Methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2-Methoxyphenyl)acetamide
• CAS No.: 93-26-5
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• European Community (EC) Number: 202-233-5
• NSC Number: 4004
• UNII: LPJ345W2VY
• DSSTox Substance ID: DTXSID0052623
• Nikkaji Number: J4.671J
• Wikidata: Q63392790
• ChEMBL ID: CHEMBL1880779
• Mol file: 93-26-5.mol

Synonyms:N-(2-Methoxyphenyl)acetamide;93-26-5;o-ACETANISIDIDE;o-Methoxyacetanilide;o-Acetanisidine;2-Methoxyacetanilide;2'-Methoxyacetanilide;Acetamide, N-(2-methoxyphenyl)-;Acetanilide, 2'-methoxy-;Acetyl-O-anisidine;NSC 4004;N-Acetyl-o-anisidine;EINECS 202-233-5;BRN 2091808;LPJ345W2VY;AI3-00799;N-(2-Methoxy-phenyl)-acetamide;NSC-4004;MFCD00026117;2-ACETAMIDOANISOLE;Aceto-o-anisidine;NSC4004;N-(2-METHOXYPHENYL) ACETAMIDE;N-acetyl-2-anisidine;2-(Acetylamino)anisole;UNII-LPJ345W2VY;Cambridge id 5137141;WLN: 1VMR BO1;N-(2-methoxyphenyl)acetamid;MLS000105047;SCHEMBL171580;N-(2-methoxyphenyl)-acetamide;N-ACETYL-ORTHO-ANISIDINE;CHEMBL1880779;DTXSID0052623;N-(2-Methoxyphenyl)acetamide #;CHEBI:143106;HMS1577L04;HMS2339K05;N-(2-Methoxyphenyl)acetamide, 95%;STL169049;AKOS000498231;SDCCGMLS-0033745.P002;AS-59474;SMR000054976;SY107302;A0018;CS-0313101;FT-0612815;D88200;A844490;AE-641/00783050;W-109344;Q63392790;Z27797377

Chemical Property of N-(2-Methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 70-74 °C(lit.)
• Refractive Index: 1.558
• Boiling Point: 304.722 °C at 760 mmHg
• PKA: 14.50±0.70(Predicted)
• Flash Point: 138.091 °C
• PSA: 38.33000
• Density: 1.127 g/cm^>3
• LogP: 1.72660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

98% ^*data from raw suppliers

o-Acetanisidide >98.0%(HPLC)(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: CC(=O)NC1=CC=CC=C1OC

Technology Process of N-(2-Methoxyphenyl)acetamide

There total 57 articles about N-(2-Methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetamide (60-35-5) + 2-Chloroanisole (766-51-8) → 2-methoxyacetanilide (93-26-5)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-butyl alcohol; at 110 ℃; for 7h;

DOI:10.1021/ja0717414

Reference yield: 99.0%

(E)-1-(2-methoxyphenyl)ethan-1-one oxime (54582-21-7) → 2-methoxyacetanilide (93-26-5)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; zinc(II) chloride; In acetonitrile; for 1h; Heating;

DOI:10.1021/ja053441x

Reference yield: 98.0%

ethanol (64-17-5) + 2-methoxy-phenylamine (90-04-0) → 2-methoxyacetanilide (93-26-5)

Guidance literature:

With oxygen; sodium hydroxide; In water; at 40 ℃; for 24h; Green chemistry;

DOI:10.1039/c3gc41117f

upstream raw materials:

2-(2-methoxyphenyl)carbamoylacetic acid

acetic anhydride

2-methoxy-phenylamine

acetic acid

Downstream raw materials:

2,2-bis-(3-acetylamino-4-methoxy-phenyl)-1,1,1-trichloro-ethane

N-(5-bromo-2-methoxyphenyl)acetamide

acetic acid-(2-methoxy-4,5-dinitro-anilide)

N-(4-hydroxy-2-methoxyphenyl)acetamide

Refernces

• 1、 -. "Continuous synthesis method 2 -acetylamino -5 - nitroanisole". Paragraph 0035. . Retrieved 2021/11/03.
• 2、 Manzoor, Shoaib,Prajapati, Santosh Kumar,Majumdar, Shreyasi,Raza, Kausar,Gabr, Moustafa T.,Kumar, Shivani,Pal, Kavita,Rashid, Haroon,Kumar, Suresh,Krishnamurthy, Sairam,Hoda, Nasimul. "Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation". . . Retrieved 2021/02/16.