Acesulfame potassium

Base Information

• Chemical Name: Acesulfame potassium
• CAS No.: 55589-62-3
• Molecular Formula: C4H5KNO4S
• Molecular Weight: 201.244
• Hs Code.: 2934990002
• European Community (EC) Number: 259-715-3
• DSSTox Substance ID: DTXSID1030606
• Wikipedia: Acesulfame_potassium
• NCI Thesaurus Code: C76512
• RXCUI: 1310545
• ChEMBL ID: CHEMBL1351474
• Mol file: 55589-62-3.mol

Synonyms:acesulfam-K;acesulfame calcium;acesulfame K;acesulfame potassium;acesulfame sodium;acetosulfam;acetosulfam potassium;acetosulfam, potassium salt;acetosulfam, sodium salt;acetosulfame;acetosulfame calcium

Chemical Property of Acesulfame potassium

Chemical Property:

• Appearance/Colour: White, odorless, free flowing crystalline powder
• Vapor Pressure: 1.03E-05mmHg at 25°C
• Melting Point: 229-232°C (dec.)
• Boiling Point: 332.7oC at 760 mmHg
• Flash Point: 155oC
• PSA: 68.82000
• Density: 1.512g/cm3
• LogP: 0.47680
• Storage Temp.: 0-6°C
• Solubility.: Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 200.94981027
• Heavy Atom Count: 11
• Complexity: 288

Purity/Quality:

99.0～101.0% ^*data from raw suppliers

Acesulfame potassium ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)[N-]S(=O)(=O)O1.[K+]
• Recent ClinicalTrials: Effects of Oral Xylitol on Subsequent Energy Intake
• Uses: 'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand. Potassium salt as sweetener for foods, cosmetics. Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature. Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.

Technology Process of Acesulfame potassium

There total 11 articles about Acesulfame potassium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetosulfam (33665-90-6) → potassium acesulfame (55589-62-3)

Guidance literature:

With potassium hydroxide; In methanol; pH=6.8; pH-value;

Reference yield: 93.1%

Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure (99911-48-5) → potassium acesulfame (55589-62-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.000277778h; under 1500.15 - 3000.3 Torr; Pressure; Temperature;

Reference yield: 85.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) → potassium acesulfame (55589-62-3)

Guidance literature:

4-methyleneoxetan-2-one; With aminosulfonic acid; triethylamine; In dichloromethane; at 20 - 25 ℃; for 0.00833333h;

With sulfur trioxide; In dichloromethane; at 20 - 40 ℃; under 0 - 7500.75 Torr;

With potassium hydroxide; In dichloromethane; water; Temperature;

upstream raw materials:

acetoacetamido

Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure

fluorosulfonyl fluoride

acetosulfam

Downstream raw materials:

acetosulfam

Refernces

• 1、 -. "Preparation method of potassium acetylsulfamate". Paragraph 0081-0088. . Retrieved 2021/10/16.
• 2、 -. "Preparation method of acesulfame potassium". Paragraph 0024; 0034; 0037-0039; 0042-0044; 0047; 0048; 0050. . Retrieved 2021/06/02.