3-tert-Butyl-2,4-dimethylpyrrole

Base Information

• Chemical Name: 3-tert-Butyl-2,4-dimethylpyrrole
• CAS No.: 151464-91-4
• Molecular Formula: C₁₀H₁₇N
• Molecular Weight: 151.252
• Mol file: 151464-91-4.mol

Synonyms:2,4-Dimethyl-3-butylpyrrole

Chemical Property of 3-tert-Butyl-2,4-dimethylpyrrole

Chemical Property:

• Vapor Pressure: 0.142mmHg at 25°C
• Refractive Index: 1.495
• Boiling Point: 223.6oC at 760 mmHg
• PKA: 18.37±0.50(Predicted)
• Flash Point: 86.7oC
• PSA: 15.79000
• Density: 0.905g/cm3
• LogP: 2.97410

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dimethyl-3-butylpyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-tert-Butyl-2,4-dimethylpyrrole

There total 5 articles about 3-tert-Butyl-2,4-dimethylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 4-butyl-3,5-dimethylpyrrole-2-carboxylate (34549-87-6) → 2,4-dimethyl-3-butylpyrrole (151464-91-4)

Guidance literature:

With potassium hydroxide; In ethylene glycol; for 1h; Heating;

Reference yield:

4-butyryl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester (50296-58-7) → 2,4-dimethyl-3-butylpyrrole (151464-91-4)

Guidance literature:

With sodium ethanolate; hydrazine hydrate; at 170 ℃;

Reference yield:

3-butylpentane-2,4-dione (1540-36-9) → 2,4-dimethyl-3-butylpyrrole (151464-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn; AcOH

2: KOH / ethane-1,2-diol

With potassium hydroxide; acetic acid; zinc; In ethylene glycol; 1: Knorr condensation;

DOI:10.1134/S1070363206110351

upstream raw materials:

4-butyryl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester

ethyl 4-butyl-3,5-dimethylpyrrole-2-carboxylate

3-butylpentane-2,4-dione

acetylacetone

Downstream raw materials:

2-formyl-3,5-dimethyl-4-butylpyrrole

ethyl 4-butyl-3,5-dimethylpyrrole-2-carboxylate

3,3',5,5'-tetramethyl-4,4'-dibutyl-2,2'-dipyrrolylmethene hydrobromide

Refernces

• 1、 Berezin,Semeikin,Antina,Pashanova,Lehedeva,Bukushina. "Synthesis and physicochemical properties of hydrobromides of alkyl-substituted dipyrrolylmethenes". . p. 1949 - 1955. Retrieved 2007/10/03.