2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE
• CAS No.: 456-00-8
• Molecular Formula: C8H8FNO^.HCl
• Molecular Weight: 189.617
• Hs Code.: 2922399090
• Mol file: 456-00-8.mol

Synonyms:Acetophenone,2-amino-4'-fluoro-, hydrochloride (8CI);Ethanone, 2-amino-1-(4-fluorophenyl)-,hydrochloride (9CI);2-Amino-1-(4-fluorophenyl)ethanone hydrochloride;a-Amino-p-fluoroacetophenone hydrochloride;

Chemical Property of 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

Chemical Property:

• Melting Point: 235-238 °C
• Boiling Point: 296.6 °C at 760 mmHg
• Flash Point: 133.2 °C
• PSA: 43.09000
• LogP: 2.46940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-1-(4-fluorophenyl)ethanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

There total 10 articles about 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-amino-4'-fluoroacetophenone hydrochloride (456-00-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 48h;

Reference yield: 97.0%

2-bromo-4'-fluoroacetophenone (403-29-2) → 2-amino-4'-fluoroacetophenone hydrochloride (456-00-8)

Guidance literature:

2-bromo-4'-fluoroacetophenone; With hexamethylenetetramine; In chloroform; at 50 ℃; for 2h;

With hydrogenchloride; In ethanol; chloroform; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.0c00200

Reference yield: 85.36%

(4-fluoro-phenacyl)-hexamethylenetetraminium; bromide (7468-87-3) → 2-amino-4'-fluoroacetophenone hydrochloride (456-00-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; Cooling with ice;

upstream raw materials:

5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid methyl ester

(4-fluoro-phenacyl)-hexamethylenetetraminium; bromide

2-Chloro-4'-fluoroacetophenone

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

5-(4-fluorophenyl)-2,3-dihydroimidazo<2,1-b>thiazole

4-Chloro-N-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-benzamide

C₂₃H₂₄ClFN₂O₂

1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol

Refernces

• 1、 Jia, Tingting,Zeng, Gongruixue,Zhang, Chong,Zeng, Linghui,Zheng, Wenya,Li, Siyao,Wu, Keyi,Shao, Jiaan,Zhang, Jiankang,Zhu, Huajian. "The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected β-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles". supporting information. p. 2657 - 2660. Retrieved 2021/03/16.
• 2、 Xu, Congjun,Han, Yufei,Xu, Sicong,Wang, Ruxin,Yue, Ming,Tian, Yu,Li, Xiaofan,Zhao, Yanfang,Gong, Ping. "Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker". . . Retrieved 2019/12/09.