Butenafine hydrochloride

Base Information

• Chemical Name: Butenafine hydrochloride
• CAS No.: 101827-46-7
• Molecular Formula: C23H27N^.HCl
• Molecular Weight: 353.19
• Hs Code.: 29214990
• European Community (EC) Number: 642-354-4
• UNII: R8XA2029ZI
• DSSTox Substance ID: DTXSID2048589
• Wikidata: Q27114276
• NCI Thesaurus Code: C47426
• RXCUI: 236558
• Metabolomics Workbench ID: 69910
• ChEMBL ID: CHEMBL1200397
• Mol file: 101827-46-7.mol

Synonyms:butenafine;butenafine HCl;butenafine hydrochloride;KP 363;KP-363;Mentax;N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine;N-4-tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride

Chemical Property of Butenafine hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 1.82E-07mmHg at 25°C
• Melting Point: 210-214 °C
• Boiling Point: 426.1 °C at 760 mmHg
• Flash Point: 187.7 °C
• PSA: 3.24000
• Density: 1.032 g/cm³
• LogP: 6.57130
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO: ≥10mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 353.1910276
• Heavy Atom Count: 25
• Complexity: 374

Purity/Quality:

98%99% ^*data from raw suppliers

Butenafine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 21
• Safety Statements: 44

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32.Cl
• Recent ClinicalTrials: Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)
• Description: Butenafine hydrochloride is a new benzylamine antifungal which appears to block the squalene epoxidation step of sterol synthesis in fungi. Active against a broad spectrum of fungi, butenafine hydrochloride is more effective in a guinea-pig model of tinea pedis than clotrimazole, naftifine and tolnaftate. Its efficacy is partially attributed to its long retention time in the skin.
• Uses: Butenafine HCl is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges. An antifungal, used to control dermal fungal infections such as athletes foot and ring worm.
• Therapeutic Function: Antifungal