Adenosine Phosphate Disodium

Base Information

• Chemical Name: Adenosine Phosphate Disodium
• CAS No.: 4578-31-8
• Molecular Formula: C10H14N5Na2O7P
• Molecular Weight: 391.188
• Hs Code.: 29349990
• European Community (EC) Number: 224-961-2
• UNII: T1WZ11DSRN
• DSSTox Substance ID: DTXSID80196617
• Nikkaji Number: J86.656C
• Wikidata: Q27155558
• Mol file: 4578-31-8.mol

Synonyms:2' Adenosine Monophosphate;2' Adenylic Acid;2'-adenosine monophosphate;2'-adenylic acid;2'-AMP;5' Adenylic Acid;5'-Adenylic Acid;5'-Phosphate, Adenosine;Acid, 2'-Adenylic;Acid, 5'-Adenylic;Adenosine 2' Phosphate;Adenosine 2'-Phosphate;Adenosine 3' Phosphate;Adenosine 3'-Phosphate;Adenosine 5' Phosphate;Adenosine 5'-Phosphate;Adenosine Monophosphate;Adenosine Phosphate Dipotassium;Adenosine Phosphate Disodium;Adenylic Acid;AMP;Dipotassium, Adenosine Phosphate;Disodium, Adenosine Phosphate;Monophosphate, 2'-Adenosine;Phosphaden;Phosphate Dipotassium, Adenosine;Phosphate Disodium, Adenosine

Chemical Property of Adenosine Phosphate Disodium

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 232-235oC
• Boiling Point: 798.5 °C at 760 mmHg
• Flash Point: 436.7 °C
• PSA: 201.54000
• LogP: -0.40540
• Storage Temp.: −20°C
• Solubility.: H2O: soluble
• Water Solubility.: Soluble in water, dimethyl sulfoxide and methanol.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 3
• Exact Mass: 391.02697330
• Heavy Atom Count: 25
• Complexity: 469

Purity/Quality:

99% ^*data from raw suppliers

Adenosine-5'-monophosphate disodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])[O-])O)O)N.[Na+].[Na+]
• Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O)N.[Na+].[Na+]
• Recent EU Clinical Trials: A double-blind, randomised, incomplete block, crossover, placebo-controlled, dose-response study to assess bronchial hyperresponsiveness and airway inflammation effects of FlutiForm? pMDI low and high dose in adult subjects with mild to moderate asthma
• Description: Adenosine 5'-monophosphate disodium salt is a modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. Adenosine 5'-monophosphate disodium salt is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase, AMP deaminase and 5?-nucleotidase.
• Uses: Adenosine 5'-monophosphate disodium salt is useful for skin rejuvenation in dermatology and aesthetic dermatology. Adenosine-5'-monophosphate disodium salt is a nucleotide involved in the reactions of cellular energy transfers. It is useful for skin rejuvenation in dermatology and aesthetic dermatology. It acts as an activator of a class of protein kinases called as AMP-activated protein kinase (AMPK). Further, it is used as a substrate for enzymes such as AMP-thymidine kinase, AMP deaminase and 5'-nucleotidase.

Technology Process of Adenosine Phosphate Disodium

There total 7 articles about Adenosine Phosphate Disodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

adenosine (58-61-7) → adenosine-5'-monophosphate disodium salt (4578-31-8) + adenosine-5'-O-(1-thiophosphate)

Guidance literature:

adenosine; In various solvent(s); at 20 - 100 ℃; for 0.333333h;

With 2,6-dimethylpyridine; trichlorophosphate; In various solvent(s); at 0 ℃; for 3h;

DOI:10.1002/hlca.200390233

Reference yield: 40.0%

C54H60N21O24P3*6C6H15N → adenosine-5'-monophosphate disodium salt (4578-31-8)

Guidance literature:

C₅₄H₆₀N₂₁O₂₄P₃*6C₆H₁₅N; With ammonium hydroxide; at 50 ℃; Sealed tube;

In methanol; water; at 50 ℃; for 5h; Sealed tube;

Sealed tube;

DOI:10.1002/ejoc.202100544

Reference yield:

adenosine-5'-O-(1-thiophosphate) → adenosine-5'-monophosphate disodium salt (4578-31-8) + (SP)-O-adenosine-5'-O-(1-thiotriphosphate) + C10H13N5O13P3(3-)*3Na(1+)

Guidance literature:

With phosphorating extract from S_. cerevisiae; at 28 ℃; for 8h;

DOI:10.1002/hlca.200390233

upstream raw materials:

Acridin-9-yl-[3-(1,13-dioxa-4,7,10,16,19,22-hexaaza-cyclotetracos-7-yl)-propyl]-amine; hydrochloride

adenosine

Diadenosine triphosphate

Downstream raw materials:

5'-adenosine monophosphate

adenosine 5'-triphosphate

adenosine-5′-diphosphate trisodium salt

dirhodium tetracetate dihydrate

Refernces

• 1、 Barai, Vladimir N.,Zinchenko, Anatoli I.,Kvach, Sergei V.,Titovich, Olga I.,Rubinova, Elena B.,Kalinichenko, Elena N.,Mikhailopulo, Igor A.. "Enzymatic synthesis of nucleoside-5′-O-(1-thiophosphates) and (S p)-adenosine-5′-O-(1-thiotriphosphate)". . p. 2827 - 2832. Retrieved 2003.
• 2、 Gibard, Clémentine,Bhowmik, Subhendu,Karki, Megha,Kim, Eun-Kyong,Krishnamurthy, Ramanarayanan. "Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions". . p. 212 - 217. Retrieved 2018/02/06.