1-Methyl-2-pyrrolidinone

Base Information Edit

Chemical Name:1-Methyl-2-pyrrolidinone
CAS No.:872-50-4
Deprecated CAS:26138-58-9,53774-35-9,57762-46-6,53774-35-9,57762-46-6
Molecular Formula:C5H9NO
Molecular Weight:99.1326
Hs Code.:2933199090
European Community (EC) Number:212-828-1
ICSC Number:0513
NSC Number:4594
UN Number:1993
UNII:JR9CE63FPM
DSSTox Substance ID:DTXSID6020856
Nikkaji Number:J26.033I
Wikipedia:N-Methyl-2-pyrrolidone
Wikidata:Q33103
NCI Thesaurus Code:C77542
RXCUI:1305552
Pharos Ligand ID:1J26YYS6USMK
Metabolomics Workbench ID:53310
ChEMBL ID:CHEMBL12543
Mol file:872-50-4.mol

Synonyms:1-methyl-2-pyrrolidinone;1-methyl-2-pyrrolidinone, 1-methyl-(14)C-labeled;1-methyl-2-pyrrolidinone, 2,3,4,5-(14)C-labeled;methyl pyrrolidone;N-methyl-2-pyrrolidinone;N-methyl-2-pyrrolidone;N-methylpyrrolidinone;N-methylpyrrolidone;pharmasolve

Suppliers and Price of 1-Methyl-2-pyrrolidinone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Methyl-2-pyrrolidinone
5g
$ 65.00

TCI Chemical
1-Methyl-2-pyrrolidone >99.0%(GC)
100mL
$ 23.00

TCI Chemical
1-Methyl-2-pyrrolidone >99.0%(GC)
25mL
$ 17.00

TCI Chemical
1-Methyl-2-pyrrolidone >99.0%(GC)
500mL
$ 36.00

Sigma-Aldrich
1-Methyl-2-pyrrolidone for Peptide Synthesis. CAS 872-50-4, pH 8.5 - 10.0 (100 g/l, H O, 20 °C)., for Peptide Synthesis
1005744000
$ 563.00

Sigma-Aldrich
1-Methyl-2-pyrrolidone for Peptide Synthesis
4 L
$ 539.27

Sigma-Aldrich
1-Methyl-2-pyrrolidinone anhydrous, 99.5%
18l
$ 1390.00

Sigma-Aldrich
1-Methyl-2-pyrrolidinone for HPLC, ≥99%
4x4l
$ 1380.00

Sigma-Aldrich
1-Methyl-2-pyrrolidone EMPLURA
8060729025
$ 1380.00

Sigma-Aldrich
1-Methyl-2-pyrrolidinone anhydrous, 99.5%
18l-p1
$ 1370.00

Total 378 raw suppliers

Chemical Property of 1-Methyl-2-pyrrolidinone Edit

Chemical Property:

Appearance/Colour:colourless or light yellow liquid with an amine odour
Vapor Pressure:0.29 mm Hg ( 20 °C)
Melting Point:-24 °C
Refractive Index:n20/D 1.479
Boiling Point:201.999 °C at 760 mmHg
PKA:-0.41±0.20(Predicted)
Flash Point:86.111 °C
PSA：20.31000
Density:1.033
LogP:0.17650
Storage Temp.:2-8°C
Sensitive.:Hygroscopic
Solubility.:ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
Water Solubility.:>=10 g/100 mL at 20 ºC
XLogP3:-0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:99.068413911
Heavy Atom Count:7
Complexity:90.1
Transport DOT Label:Combustible Liquid

Purity/Quality:

99.85% ^*data from raw suppliers

1-Methyl-2-pyrrolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xi
Hazard Codes:T,Xi
Statements: 45-65-36/38-36/37/38-61-10-46
Safety Statements: 41-45-53-62-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Solvents -> Other Solvents
Canonical SMILES:CN1CCCC1=O
Recent ClinicalTrials:NMP in Relapsed / Refractory Myeloma
Inhalation Risk:A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
Effects of Short Term Exposure:The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness.
Effects of Long Term Exposure:Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Chemical Properties and Reactions Hydroperoxide Production: NMP produces hydroperoxide when heated in the presence of oxygen via a free radical autoxidation mechanism.
Structural Similarity with Povidone: NMP is structurally similar to povidone, making it a valuable alternative for studying the miscibility of crystalline drugs in povidone excipients.
Molecular Interaction: NMP interacts with drugs through hydrophobic interactions, generating stable complexes and facilitating drug stabilization in dissolved form.
Industrial Uses Solvent in Various Industries: Widely used in the manufacture of lithium batteries, circuit boards, liquid crystal electronics, semiconductors, and insulating materials.
Manufacturing Process: Commercial manufacture involves synthesis from 纬-butyrolactone and monomethylamine, followed by dehydration through distillation to produce finished NMP.
Wastewater Treatment: Effective treatment of wastewater from NMP production is necessary due to its toxicity and pending regulation.
Biodegradation Biodegradability: NMP is biodegradable in aerobic or anoxic conditions.
Transformation Pathway: Biodegradation involves transformation to various intermediates, including 1-methyl-5-hydroxy-2-pyrrolidone, 1-methyl-2,5-pyrrolidinedione, and 2-hydoxy-N-methylsuccinimide, followed by further reductions and cleavage reactions.
Mineralization: Succinic acid and ammonia are generated through transformations, with succinic acid entering the Krebs cycle for complete mineralization and ammonia being oxidized and cleaved to form CO2 and ammonia.
Synthesis of N-Doped Carbon Quantum Dots (N-CQDs) Large-Scale Synthesis: NMP can be used as a single feedstock to prepare N-CQDs in a large scale using a reflux-assisted method at atmospheric pressure.

Technology Process of 1-Methyl-2-pyrrolidinone

There total 101 articles about 1-Methyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%