CID 5702712

Base Information

• Chemical Name: CID 5702712
• CAS No.: 26386-88-9
• Molecular Formula: C12H10N3O3P
• Molecular Weight: 275.203
• Hs Code.: 29299000
• Mol file: 26386-88-9.mol

Synonyms:AC-19341

Chemical Property of CID 5702712

Chemical Property:

• Appearance/Colour: colourless or faintly yellow liquid
• Refractive Index: n20/D 1.551(lit.)
• Boiling Point: 157°C0.17mm Hg(lit.)
• Flash Point: >230°F
• PSA: 95.09000
• Density: 1.277 g/mL at 25 °C(lit.)
• LogP: 4.01556
• Storage Temp.: 2-8°C
• Water Solubility.: insoluble
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 275.04597819
• Heavy Atom Count: 19
• Complexity: 348

Purity/Quality:

99% ^*data from raw suppliers

Diphenyl phosphoryl azide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OP(=O)(N=[N+]=[N-])OC2=CC=CC=C2
• Uses: Diphenylphosphoryl azide (DPPA or diphenyl phosphorazidate, (PhO)2P(O)N3) is a very toxic and potentially explosive organic compound. DPPA has been found to be effective for a variety of organic reactions as a versatile synthetic reagent. It is widely used in synthesis of other organic compounds especially as a reagent for the synthesis of peptides by virtue of its reactions with carboxylic acids leading to either the urethane or the amide.

Technology Process of CID 5702712

There total 6 articles about CID 5702712 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chlorophosphoric acid diphenyl ester (2524-64-3) → diphenyl phosphoryl azide (26386-88-9)

Guidance literature:

With sodium azide; In acetone; at 25 ℃; for 4h;

Reference yield: 76.0%

diphenyl hydrogen phosphite (4712-55-4) → diphenyl phosphoryl azide (26386-88-9)

Guidance literature:

With tetrachloromethane; sodium azide; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1055/s-2004-834898

Reference yield:

→ diphenyl phosphoryl azide (26386-88-9)

Guidance literature:

Phosphorsaeurediphenylesterchlorid, NaN3;

upstream raw materials:

chlorophosphoric acid diphenyl ester

diphenyl hydrogen phosphite

phenol

diphenylphosphoroamidate

Downstream raw materials:

diphenyl N-<2-(6-methoxy-2-naphthyl)-1-pyrrolidinopropylidene>phosphoramidate

diphenyl N-<2-(4-isobutylphenyl)-1-pyrrolidinopropylidene>

[1-Indan-1-yl-1-morpholin-4-yl-meth-(Z)-ylidene]-phosphoramidic acid diphenyl ester

[1-Indan-1-yl-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-phosphoramidic acid diphenyl ester

Refernces

• 1、 Shi, Enxue,Xiao, Junhua,Pei, Chengxin,Chen, Jisheng. "Microwave-assisted solvent-free synthesis of pseudohalophosphates". . p. 3085 - 3088. Retrieved 2011.
• 2、 -. "Applications of continuous micro-channel reactor in pharmaceutical synthesis". Paragraph 0041-0053. . Retrieved 2019/10/01.
• 3、 Das, Debapratim,Samanta, Rajarshi. "Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones". supporting information. p. 379 - 384. Retrieved 2017/12/26.