(Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid

Base Information

• Chemical Name: (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid
• CAS No.: 74440-02-1
• Molecular Formula: C11H15N3O5S
• Molecular Weight: 301.323
• Hs Code.: 2934100090
• Mol file: 74440-02-1.mol

Synonyms:2-(2-Aminothiazol-4-yl)-2-[(Z)-tert-butoxycarbonylmethoxyimino]aceticacid;4-Thiazoleaceticacid, 2-amino-a-[[2-(1,1-dimethylethoxy)-2-oxoethoxy]imino]-,(Z)-;

Chemical Property of (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid

Chemical Property:

• Vapor Pressure: 3.93E-10mmHg at 25°C
• Melting Point: 175-176 °C (decomp)
• Refractive Index: 1.601
• Boiling Point: 482.8 °C at 760 mmHg
• PKA: 2?+-.0.10(Predicted)
• Flash Point: 245.8 °C
• PSA: 152.34000
• Density: 1.43 g/cm³
• LogP: 1.45350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO, Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

(Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A cephalosporin derivatives

Technology Process of (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid

There total 1 articles about (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-nitrobenzyl (Z)-2-(2-amino-4-thiazolyl)-2-(t-butoxycarbonylmethoxyimino)acetate → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[2-(tert-butoxy)-2-oxoethoxy]imino]acetic acid (74440-02-1)

Guidance literature:

With hydrogenchloride; palladium; In tetrahydrofuran; water;

Reference yield: 90.5%

2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6) + (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[2-(tert-butoxy)-2-oxoethoxy]imino]acetic acid (74440-02-1) → (2-Amino-thiazol-4-yl)-[(Z)-tert-butoxycarbonylmethoxyimino]-acetic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1080/00397919808006831

Reference yield: 87.3%

diethyl chlorophosphate (814-49-3) + (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[2-(tert-butoxy)-2-oxoethoxy]imino]acetic acid (74440-02-1) → [1-(2-Amino-thiazol-4-yl)-2-(diethoxy-phosphoryloxy)-2-oxo-eth-(Z)-ylideneaminooxy]-acetic acid tert-butyl ester (204185-34-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h;

DOI:10.1080/00397919808005071

Downstream raw materials:

[1-(2-Amino-thiazol-4-yl)-2-(diethoxy-phosphoryloxy)-2-oxo-eth-(Z)-ylideneaminooxy]-acetic acid tert-butyl ester

Refernces