6-Bromo-2-pyridinecarbonitrile

Base Information

• Chemical Name: 6-Bromo-2-pyridinecarbonitrile
• CAS No.: 122918-25-6
• Molecular Formula: C6H3BrN2
• Molecular Weight: 183.007
• Hs Code.: 29333990
• Mol file: 122918-25-6.mol

Synonyms:6-Bromopyridine-2-carbonitrile;

Chemical Property of 6-Bromo-2-pyridinecarbonitrile

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 100-104 °C
• Refractive Index: 1.612
• Boiling Point: 269.732 °C at 760 mmHg
• PKA: -4.76±0.10(Predicted)
• Flash Point: 116.93 °C
• PSA: 36.68000
• Density: 1.726 g/cm³
• LogP: 1.71578
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-R41-R37/38-R22
• Safety Statements: 26-39-S39-S26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-pyridinecarbonitrile

There total 6 articles about 6-Bromo-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-bromo-pyridine-2-carboxylic acid amide (25194-52-9) → 6-bromopyridin-2-carbonitrile (122918-25-6)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jm0613525

Reference yield: 86.0%

6-bromopyridine-2-carbaldehyde oxime → 6-bromopyridin-2-carbonitrile (122918-25-6)

Guidance literature:

With 4-nitro-1-((trifluoromethyl)sulfonyl)-1H-imidazole; triethylamine; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere; Sealed tube;

DOI:10.1039/d0cc00188k

Reference yield: 67.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → 6-bromopyridin-2-carbonitrile (122918-25-6)

Guidance literature:

6-bromo-2-pyridinecarbaldehyde; With hydroxylamine hydrochloride; triethylamine; In chloroform; at 20 ℃;

With bis(trichloromethyl) carbonate; In chloroform; at 20 ℃;

DOI:10.1021/jm900805v

upstream raw materials:

6-bromo-pyridine-2-carboxylic acid amide

6-bromo-pyridine-2-carboxylic acid

6-bromo-2-pyridinecarbaldehyde

2,6-Dibromopyridine

Downstream raw materials:

6-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)picolinonitrile

6-(4-vinylphenoxy)-2-pyridinecarbonitrile

2-[(S)-4,5-dihydro-4-tert-butyl-1,3-oxazol-2-yl]-6-(4-vinylphenoxy)pyridine

2-(4-bromophenoxy)-6-pyridinecarbonitrile

Refernces

• 1、 Altmann, Eva,Aichholz, Reiner,Betschart, Claudia,Buhl, Thomas,Green, Jonathan,Irie, Osamu,Teno, Naoki,Lattmann, René,Tintelnot-Blomley, Marina,Missbach, Martin. "2-Cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K". . p. 591 - 594. Retrieved 2007.
• 2、 Zhang, Wei,Lin, Jin-Hong,Zhang, Pengfei,Xiao, Ji-Chang. "A convenient reagent for the conversion of aldoximes into nitriles and isonitriles". supporting information. p. 6221 - 6224. Retrieved 2020/06/29.