Loxoprofen

Base Information Edit

Chemical Name:Loxoprofen
CAS No.:68767-14-6
Molecular Formula:C₁₅H₁₈O₃
Molecular Weight:246.306
Hs Code.:2918300090
European Community (EC) Number:807-110-5
UNII:3583H0GZAP
DSSTox Substance ID:DTXSID1045164
Nikkaji Number:J22.351D
Wikipedia:Loxoprofen
Wikidata:Q2759348
NCI Thesaurus Code:C81064
Pharos Ligand ID:L329KSQP2VHW
Metabolomics Workbench ID:49627
ChEMBL ID:CHEMBL19299
Mol file:68767-14-6.mol

Synonyms:156-S;2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid;2-OCPPP;CS 600;CS-600;loxoprofen;loxoprofen alcohol;loxoprofen sodium dihydrate;loxoprofen sodium, (R*,S*)-isomer;sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate;sodium loxoprofen

Suppliers and Price of Loxoprofen

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Loxoprofen
100mg
$ 185.00

TCI Chemical
Loxoprofen >97.0%(HPLC)(T)
5g
$ 103.00

Sigma-Aldrich
Loxoprofen
5mg
$ 323.00

Medical Isotopes, Inc.
Loxoprofen
10 mg
$ 650.00

Matrix Scientific
2-(4-((2-Oxocyclopentyl)methyl)-phenyl)propanoic acid 95+%
1g
$ 90.00

Matrix Scientific
2-(4-((2-Oxocyclopentyl)methyl)-phenyl)propanoic acid 95+%
5g
$ 270.00

Matrix Scientific
2-(4-((2-Oxocyclopentyl)methyl)-phenyl)propanoic acid 95+%
10g
$ 432.00

DC Chemicals
LoxoprofenSodium >99%
1 g
$ 800.00

DC Chemicals
LoxoprofenSodium >99%
250 mg
$ 400.00

DC Chemicals
LoxoprofenSodium >99%
100 mg
$ 200.00

Total 147 raw suppliers

Chemical Property of Loxoprofen Edit

Chemical Property:

Appearance/Colour:Colorless oily matter
Vapor Pressure:9.92E-08mmHg at 25°C
Melting Point:108.5 - 111oC
Refractive Index:1.567
Boiling Point:417.9 °C at 760 mmHg
PKA:4.39±0.10(Predicted)
Flash Point:220.7 °C
PSA：54.37000
Density:1.182 g/cm³
LogP:2.78640
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:246.125594432
Heavy Atom Count:18
Complexity:316

Purity/Quality:

99% ^*data from raw suppliers

Loxoprofen ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)O
Recent ClinicalTrials:Comparison Of Celecoxib 200 Mg Bid, Loxoprofen Sodium 60 Mg Tid And Placebo In Low Back Pain In Japan
Recent EU Clinical Trials:Randomized, controlled, multi-center trial to evaluate the efficacy and safety of a Loxoprofen sodium 60 mg medicated plaster vs. placebo and vs. a marketed comparator in the local symptomatic and short term treatment of pain in acute strains, sprains or bruises of the muscles or joints following blunt trauma, e.g. sports injuries.
Recent NIPH Clinical Trials:Trial of antiinflammatory agent effect for TMD(myalgia of the masticatory muscle and arthralgia of the temporomandibular joint).
Uses Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.

Technology Process of Loxoprofen

There total 39 articles about Loxoprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%