(S)-(+)-2-Chlorophenylglycine methyl ester

Base Information

• Chemical Name: (S)-(+)-2-Chlorophenylglycine methyl ester
• CAS No.: 141109-14-0
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Hs Code.: 2922499990
• Mol file: 141109-14-0.mol

Synonyms:Benzeneaceticacid, a-amino-2-chloro-, methyl ester,(+)-;Benzeneacetic acid, a-amino-2-chloro-, methyl ester, (aS)-;(S)-Methyl 2-(o-chlorophenyl)glycinate;Methyl(2S)-(+)-amino(2-chlorophenyl)acetate;

Chemical Property of (S)-(+)-2-Chlorophenylglycine methyl ester

Chemical Property:

• Appearance/Colour: light yellow to yellow liquid
• Boiling Point: 270.1 °C at 760 mmHg
• PKA: 6.15±0.10(Predicted)
• Flash Point: 117.2 °C
• PSA: 52.32000
• Density: 1.258 g/cm³
• LogP: 2.21310
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(S)-(+)-2-Chlorophenylglycinemethylestertartratesalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-(+)-2-Chlorophenylglycine methyl ester tartrate

Technology Process of (S)-(+)-2-Chlorophenylglycine methyl ester

There total 17 articles about (S)-(+)-2-Chlorophenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9) → 2-(2-chlorophenyl)glycine methyl ester hydrochloride (141109-14-0,141109-16-2,141109-13-9)

Guidance literature:

With sulfuric acid; at 35 - 65 ℃; for 21h;

Reference yield: 95.0%

2-chlorophenylglycine methyl ester L-(+)-tartaric acid (141109-15-1) → methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate (141109-14-0)

Guidance literature:

In methanol; for 0.5h; Reflux;

Reference yield: 94.0%

methanol (67-56-1) + (S)-2-(2-chlorophenyl)glycinamide hydrochloride (1198213-98-7) → methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate (141109-14-0)

Guidance literature:

methanol; With sulfuric acid; Cooling with ice; Reflux;

(S)-2-(2-chlorophenyl)glycinamide hydrochloride; at 20 ℃; Reflux;

With sodium hydroxide; In water;

DOI:10.1021/op900243c

upstream raw materials:

L-(+)-tartaric acid salt of α-amino-(2-chlorophenyl)acetic acid methyl ester

methanol

2-amino-(2-chlorophenyl)ethanoic acid

2-chlorophenylglycine methyl ester L-(+)-tartaric acid

Downstream raw materials:

methyl [2-(thien-2-yl)ethylamino](2-chlorophenyl)-acetate hydrochloride

2-chlorophenylglycine methyl ester L-(+)-tartaric acid

(S)-(+)-clopidogrel

(S)-(+)-clopidogrel bisulfate

Refernces

• 1、 Junge, Thorsten,Titze, Marvin,Frey, Wolfgang,Peters, René. "Asymmetric Hydrocyanation of N-Phosphinoyl Aldimines with Acetone Cyanohydrin by Cooperative Lewis Acid/Onium Salt/Br?nsted Base Catalysis". . p. 1509 - 1512. Retrieved 2021/02/09.
• 2、 -. "Preparation method of clopidogrel hydrogen sulfate crystal form II". Paragraph 0034; 0054; 0070. . Retrieved 2020/02/29.