5-Sulfo-2,3,3-trimethyl indolenine sodium salt

Base Information

• Chemical Name: 5-Sulfo-2,3,3-trimethyl indolenine sodium salt
• CAS No.: 132557-72-3
• Molecular Formula: C11H13NO3S
• Molecular Weight: 239.295
• Hs Code.: 2933990090
• Mol file: 132557-72-3.mol

Synonyms:2,3,3-Trimethylindole-5-sulfonic acid;

Chemical Property of 5-Sulfo-2,3,3-trimethyl indolenine sodium salt

Chemical Property:

• Melting Point: 290-295℃
• Refractive Index: 1.611
• PKA: -1.45±0.60(Predicted)
• PSA: 77.94000
• Density: 1.34 g/cm³
• LogP: 2.49070
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3,3-Trimethyl-3H-indole-5-sulfonicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Sulfo-2,3,3-trimethyl indolenine sodium salt

There total 4 articles about 5-Sulfo-2,3,3-trimethyl indolenine sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methyl-butan-2-one (563-80-4) + 4-hydrazino-benzenesulfonic acid (98-71-5) → 2,3,3-trimethylindole-5-sulfonic acid (132557-72-3)

Guidance literature:

With acetic acid; for 3h; Concentration; Reflux;

Reference yield:

potassium 2,3,3-trimethylindole-5-sulfonate → 2,3,3-trimethylindole-5-sulfonic acid (132557-72-3)

Guidance literature:

With Dowex, strongly acidic hydrogen ion exchange resin; In water;

Reference yield:

p-hydrazinobenzenesulfonic acid hydrochloride + 3-methyl-butan-2-one (563-80-4) → 2,3,3-trimethylindole-5-sulfonic acid (132557-72-3)

Guidance literature:

With acetic acid; Reflux;

DOI:10.3390/molecules181113588

upstream raw materials:

3-methyl-butan-2-one

4-hydrazino-benzenesulfonic acid

Downstream raw materials:

C₃₁H₃₈N₂O₈S₂

1-(5-carboxypentyl)-2-[3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)-2,3-dihydro-1H-indol-2-yliden]-1,3-pentadienyl-3,3-dimethyl-3H-indolium-5-sulfonate

C₂₄H₂₆N₂O₄S

Cy₇-COOH

Refernces

• 1、 K?nig, Sandra G.,Kr?mer, Roland. "Accessing Structurally Diverse Near-Infrared Cyanine Dyes for Folate Receptor-Targeted Cancer Cell Staining". . p. 9306 - 9312. Retrieved 2017.
• 2、 Hayase, Shuzi,Pandey, Shyam S.,Pradhan, Anusha,Vats, Ajendra Kumar. "Synthesis, photophysical characterization and dye adsorption behavior in unsymmetrical squaraine dyes with varying anchoring groups". . . Retrieved 2020.
• 3、 Sugahara, Akira,Tanaka, Naru,Okazawa, Atsushi,Matsushita, Nobuyuki,Kojima, Norimichi. "Photochromic property of anionic spiropyran with sulfonate-substituted indoline moiety". . p. 281 - 283. Retrieved 2014.
• 4、 Choi, Hak Soo,Nasr, Khaled,Alyabyev, Sergey,Feith, Dina,Lee, Jeong Heon,Kim, Soon Hee,Ashitate, Yoshitomo,Hyun, Hoon,Patonay, Gabor,Strekowski, Lucjan,Henary, Maged,Frangioni, John V.. "Synthesis and in vivo fate of zwitterionic near-infrared fluorophores". . p. 6258 - 6263. Retrieved 2011.
• 5、 Chen, Hsiang-Jung,Chew, Chee Ying,Chang, En-Hao,Tu, Yu-Wei,Wei, Li-Yu,Wu, Bo-Han,Chen, Chien-Hung,Yang, Ya-Ting,Huang, Su-Chin,Chen, Jen-Kun,Chen, I-Chia,Tan, Kui-Thong. "S - Cis Diene Conformation: A New Bathochromic Shift Strategy for Near-Infrared Fluorescence Switchable Dye and the Imaging Applications". . p. 5224 - 5234. Retrieved 2018.