3-Piperazinobenzisothiazole hydrochloride

Base Information

• Chemical Name: 3-Piperazinobenzisothiazole hydrochloride
• CAS No.: 144010-02-6
• Molecular Formula: C₁₁H₁₃N₃S*ClH
• Molecular Weight: 255.771
• Mol file: 144010-02-6.mol

Synonyms:3-Piperazinobenzisothiazole hydrochloride

Chemical Property of 3-Piperazinobenzisothiazole hydrochloride

Chemical Property:

• Vapor Pressure: 0.000323mmHg at 25°C
• Boiling Point: 320.2oC at 760mmHg
• Flash Point: 147.4oC
• PSA: 56.40000
• LogP: 2.90170
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-(Piperazin-1-yl)benzo[d]isothiazolexhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperazinobenzisothiazole hydrochloride

There total 14 articles about 3-Piperazinobenzisothiazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

piperazine (110-85-0) + benzo[d]isothiazole-3-p-nitrobenzenesulfonate → 3-(piperazin-1-yl)-1,2-benzisothiazole hydrochloride (133070-64-1,144010-02-6)

Guidance literature:

With hydrogenchloride; In water; at 60 - 70 ℃; Large scale;

Reference yield: 80.0%

piperazine (110-85-0) + 3-chloro-1,2-benzisothiazole (7716-66-7) → 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride (87691-88-1,133070-64-1,144010-02-6)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; toluene; tert-butyl alcohol;

Reference yield: 80.0%

piperazine (110-85-0) + benzo[d]isothiazole-3-yl methanesulfonate → 3-(piperazin-1-yl)-1,2-benzisothiazole hydrochloride (133070-64-1,144010-02-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 50 - 60 ℃; Large scale;

upstream raw materials:

piperazine

3-chloro-1,2-benzisothiazole

2,2 dithiobis(benzonitrile)

trimethyleneglycol

Downstream raw materials:

lurasidone

(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate

Refernces

• 1、 -. "Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole". . . Retrieved 2008/06/13.
• 2、 Walinsky, Stanley W.,Fox, Darrell E.,Lambert, John F.,Sinay, Terry G.. "New disulfide route to 3-(1-piperazinyl)-1,2-benzisothiazole. Nucleus for atypical antipsychotic drugs". . p. 126 - 130. Retrieved 2013/09/08.