4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride

Base Information

• Chemical Name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride
• CAS No.: 28783-41-7
• Molecular Formula: C7H10ClNS
• Molecular Weight: 175.682
• Hs Code.: 29333990
• European Community (EC) Number: 249-220-0
• UNII: E0HB70DQ7N
• DSSTox Substance ID: DTXSID40951426
• Wikidata: Q27276705
• Mol file: 28783-41-7.mol

Synonyms:28783-41-7;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride;4,5,6,7-tetrahydrothieno[3,2,c] pyridine hydrochloride;4,5,6,7-tetrahydrothieno[3,2-c]pyridine hcl;4H,5H,6H,7H-thieno[3,2-c]pyridine hydrochloride;MFCD05861485;4,5,6,7-Tetrahydrothieno(3,2-c)pyridinium chloride;4,5,6,7-tetrahydrothieno(3,2-c)pyridine hydrochloride;4,5,6,7-Tetrahydrothieno[3,2,c]pyridine hydrochloride;Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride;4,5,6,7-tetrahydrothieno[3,2-c]pyridinehydrochloride;4,5,6,7-tetrahydrothieno[3,2-c]pyridine;hydrochloride;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine, HCl;4,5,6,7-tetrahydro-thieno[3,2-c]pyridine hydrochloride;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine (hydrochloride);4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride;4,5,6,7-Tetrahydrothieno[3,2,c] Pyridine HCl;4,5,6,7-tetrahydrothieno-(3,2-c)pyridine hydrochloride;4,5,6,7-tetrahydrothieno-[3,2-c]pyridine hydrochloride;Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1);THIENO(3,2-C)PYRIDINE, 4,5,6,7-TETRAHYDRO-, HYDROCHLORIDE (1:1);4H,5H,6H,7H-thieno[3,2-c]pyridine,hydrochloride;C7H9NS.ClH;C7-H9-N-S.Cl-H;SCHEMBL366688;DTXSID40951426;QMXCTKPNQFJZGK-UHFFFAOYSA-N;CS-D0183;AKOS005073535;AC-1534;CS-O-07687;MD-0219;SB13200;HY-21089;SY002037;AM20090376;FT-0630197;T2770;EN300-26520;4,5,6,7-tetrahydrothieno[3,2-c]pyridine HCl salt;6,7-dihydro-4h-thieno[3,2-c]pyridine hydrochloride;Q-200418;Q27276705;4,5,6,7-Tetrahydrothieno [3,2,c]pyridine hydrochloride;F2145-0241;Z271099584;4,5,6,7 -tetrahydro-thieno[3,2-c]pyridine hydrochloride;4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine hydrochloride;4,5,6,7-tetrahydrothieno (3,2-c) pyridine hydrochloride;4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine--hydrogen chloride (1/1);4 pound not5 pound not6 pound not7-Tetrahydrothieno[3 pound not2-c]pyridine hydrochloride;Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (8CI,9CI)

Chemical Property of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride

Chemical Property:

• Appearance/Colour: Off-White Solid
• Vapor Pressure: 0.0331mmHg at 25°C
• Melting Point: 212-215°C
• Boiling Point: 242.9 °C at 760 mmHg
• Flash Point: 100.7 °C
• PSA: 40.27000
• Density: 1.143g/cm3
• LogP: 2.52460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO, Methanol, Water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 175.0222482
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC2=C1SC=C2.Cl
• Uses: An intemediate of Clopidogrel and Prasugrel.

Technology Process of 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride

There total 7 articles about 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[2-(2-thyenyl)ethyl]amine (30433-91-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7)

Guidance literature:

[2-(2-thyenyl)ethyl]amine; formaldehyd; In dichloromethane; at 40 - 45 ℃;

With hydrogenchloride; In dichloromethane; water; N,N-dimethyl-formamide; at 20 - 70 ℃;

Reference yield: 82.0%

N-(thiophen-2-ylethyl)methyleneamine (111954-31-5) → 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 10 - 85 ℃; for 3h;

Reference yield: 82.0%

N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (68559-49-9) → 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7)

Guidance literature:

N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine; With sodium hydroxide; In methanol; for 12h; Reflux;

With hydrogenchloride; In 1,4-dioxane; pH=1;

DOI:10.1021/ja108865w

upstream raw materials:

[2-(2-thyenyl)ethyl]amine

formaldehyd

N-(thiophen-2-ylethyl)methyleneamine

N-methoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Downstream raw materials:

clopidogrel

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid methyl ester-d3

Refernces

• 1、 -. "Synthesis method of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride". Paragraph 0018. . Retrieved 2017/09/02.
• 2、 Shaw, Scott A.,Balasubramanian, Balu,Bonacorsi, Samuel,Cortes, Janet Caceres,Cao, Kevin,Chen, Bang-Chi,Dai, Jun,Decicco, Carl,Goswami, Animesh,Guo, Zhiwei,Hanson, Ronald,Humphreys, W. Griffith,Lam, Patrick Y. S.,Li, Wenying,Mathur, Arvind,Maxwell, Brad D.,Michaudel, Quentin,Peng, Li,Pudzianowski, Andrew,Qiu, Feng,Su, Shun,Sun, Dawn,Tymiak, Adrienne A.,Vokits, Benjamin P.,Wang, Bei,Wexler, Ruth,Wu, Dauh-Rurng,Zhang, Yingru,Zhao, Rulin,Baran, Phil S.. "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development". . p. 7019 - 7032. Retrieved 2015/07/27.