Ropivacaine hydrochloride

Base Information

• Chemical Name: Ropivacaine hydrochloride
• CAS No.: 132112-35-7
• Molecular Formula: C17H29ClN2O2
• Molecular Weight: 328.882
• Hs Code.: 2933399090
• European Community (EC) Number: 663-286-1
• UNII: V910P86109
• DSSTox Substance ID: DTXSID80927544
• Wikidata: Q27116333
• NCI Thesaurus Code: C52198
• RXCUI: 236539
• Mol file: 132112-35-7.mol

Synonyms:2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-propyl-, monohydrochloride,monohydrate, (2S)- (9CI);2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-propyl-, monohydrochloride,monohydrate, (S)-;Ropivacaine hydrochloridemonohydrate;Ropivacaine HCL;(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride;

Chemical Property of Ropivacaine hydrochloride

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 1.18E-10mmHg at 25°C
• Melting Point: 267-269 °C
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• PSA: 41.57000
• LogP: 4.25500
• Storage Temp.: Refrigerator
• Solubility.: H2O: soluble5mg/mL, clear
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 328.1917559
• Heavy Atom Count: 22
• Complexity: 308

Purity/Quality:

99% ^*data from raw suppliers

Ropivacaine Hydrochloride Monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,Xi
• Statements: 26/27/28-41
• Safety Statements: 22-36/37/39-45-39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl
• Isomeric SMILES: CCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.O.Cl
• Recent ClinicalTrials: Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery
• Recent EU Clinical Trials: Comparison of ultrasound-guided PENG block and supra-inguinal fascia iliaca compartment block for postoperative pain and early motor recovery after total hip arthroplasty: a randomized controlled non-inferiority clinical trial
• Recent NIPH Clinical Trials: Study of rectus sheath block in transabdominal preperitoneal approach (TAPP) for laparoscopic inguinal hernia surgery
• Description: (–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.
• Uses: Anesthetic (local) Anesthetic (local). Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Technology Process of Ropivacaine hydrochloride

There total 3 articles about Ropivacaine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ropivacaine (84057-95-4,98717-16-9) → ropivacaine hydrochloride monohydrate (132112-35-7)

Guidance literature:

With hydrogenchloride; water; In acetone; pH=2; Product distribution / selectivity; Heating / reflux;

Reference yield: 80.0%

→ ropivacaine hydrochloride monohydrate (132112-35-7)

Guidance literature:

Reference yield:

ropivacaine hydrochloride (98717-15-8) → ropivacaine hydrochloride monohydrate (132112-35-7)

Guidance literature:

With water; at 40 ℃; for 20h; Product distribution / selectivity;

upstream raw materials:

ropivacaine hydrochloride

ropivacaine

Refernces

• 1、 -. "Process for the preparation of ropivacaine hydrochloride monohydrate". . . Retrieved 2008/06/13.