Ethambutol

Base Information Edit

Chemical Name:Ethambutol
CAS No.:74-55-5
Molecular Formula:C10H24N2O2
Molecular Weight:204.313
Hs Code.:2922191000
European Community (EC) Number:200-810-6,213-970-7
UNII:8G167061QZ
DSSTox Substance ID:DTXSID8023006,DTXSID901028179
Nikkaji Number:J5.261B
Wikipedia:Ethambutol
Wikidata:Q412318
NCI Thesaurus Code:C61755
RXCUI:4110
Metabolomics Workbench ID:42713
ChEMBL ID:CHEMBL44884
Mol file:74-55-5.mol

Synonyms:Dexambutol;EMB Fatol;EMB Hefa;EMB-Fatol;EMB-Hefa;Etambutol Llorente;Ethambutol;Ethambutol Hydrochloride;Etibi;Hydrochloride, Ethambutol;Llorente, Etambutol;Miambutol;Myambutol

Suppliers and Price of Ethambutol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
EMB
50ug
$ 664.00

TRC
Ethambutol
50g
$ 330.00

Crysdot
Ethambutol 98+%
25g
$ 270.00

Biorbyt Ltd
EMB
10 μg
$ 290.70

ApexBio Technology
Ethambutol
5g
$ 90.00

ApexBio Technology
Ethambutol
1g
$ 49.00

Ambeed
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) 98+%
1g
$ 100.00

Ambeed
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) 98+%
250mg
$ 41.00

Ambeed
(2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) 98+%
100mg
$ 22.00

Total 90 raw suppliers

Chemical Property of Ethambutol Edit

Chemical Property:

Appearance/Colour:white crystalline hygroscopic powder
Vapor Pressure:3.9E-06mmHg at 25°C
Melting Point:199 - 204oC
Refractive Index:1.477
Boiling Point:345.342 °C at 760 mmHg
PKA:pKa 6.6 (H2O) (Uncertain);9.5(H3O) (Uncertain)
Flash Point:113.661 °C
PSA：64.52000
Density:0.987 g/cm³
LogP:0.48920
Storage Temp.:-20°C
Water Solubility.:Soluble in water. Also soluble in chloroform and methylene chloride
XLogP3:-0.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:204.183778013
Heavy Atom Count:14
Complexity:109

Purity/Quality:

99% ^*data from raw suppliers

EMB ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antituberculosis Agents
Canonical SMILES:CCC(CO)NCCNC(CC)CO
Isomeric SMILES:CC[C@@H](CO)NCCN[C@@H](CC)CO
Recent ClinicalTrials:Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex
Recent EU Clinical Trials:ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Mycobacterial (NTM) Lung Infection Caused by Mycobacterium avium Complex (MAC)
Recent NIPH Clinical Trials:A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatmentrefractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
Uses Antibacterial. Ethambutol is an antitubercular antibiotic.
Indications Ethambutol is a water-soluble, heat-stable compound that acts by inhibition of arabinosyl transferase enzymes that are involved in cell wall biosynthesis. Nearly all strains of M. tuberculosis and M. kansasii and most strains of Mycobacterium avium-intracellulare are sensitive to ethambutol. Drug resistance relates to point mutations in the gene (EmbB) that encodes the arabinosyl transferases that are involved in mycobacterial cell wall synthesis.
Therapeutic Function Antitubercular
Clinical Use Tuberculosis (initial intensive phase of short-course therapy) Other mycobacterioses (M. kansasii, M. xenopi, M. malmoense and the M. avium complex) (with appropriate additional drugs) Ethambutol has replaced aminosalicylic acid as a first-line antitubercular drug. It is commonly included as a fourth drug, along with isoniazid, pyrazinamide, and rifampin, in patients infected with MDR strains. It also is used in combination in the treatment of M. aviumintracellulare infection in AIDS patients.

Technology Process of Ethambutol

There total 14 articles about Ethambutol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.01%