Hydroxyapatite

Base Information

• Chemical Name: Hydroxyapatite
• CAS No.: 1306-06-5
• Deprecated CAS: 12440-80-1,136841-77-5,196875-13-5,1059174-00-3,221359-86-0,205873-50-3,29796-40-5,1337-78-6,947383-76-8,1398505-50-4
• Molecular Formula: Ca5^.(OH)^.(PO4)3
• Molecular Weight: 502.31
• Hs Code.: 28352600
• European Community (EC) Number: 215-145-7,235-330-6
• UNII: 91D9GV0Z28
• DSSTox Substance ID: DTXSID50872537
• Wikipedia: Hydroxyapatite,Hydroxylapatite
• Wikidata: Q27271399
• NCI Thesaurus Code: C84224
• ChEMBL ID: CHEMBL2218916
• Mol file: 1306-06-5.mol

Synonyms:Alveograf;Calcitite;Calcium Hydroxyapatite;Durapatite;Hydroxyapatite;Hydroxyapatite, Calcium;Hydroxylapatite;Interpore 200;Interpore 500;Interpore-200;Interpore-500;Interpore200;Interpore500;Osprovit;Ossein Hydroxyapatite Compound;Ossein-Hydroxyapatite Compound;Ossopan;Osteogen;Periograf

Chemical Property of Hydroxyapatite

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 1100 °C(lit.)
• Boiling Point: 158oC at 760 mmHg
• PSA: 119.12000
• Density: 3.076 g/cm3(Temp: 18 °C)
• LogP: 0.20920
• Storage Temp.: −20°C
• Solubility.: H2O: 0.3 mg/mL, clear, colorless
• Water Solubility.: insoluble H2O [MER06]
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 0
• Exact Mass: 501.675955
• Heavy Atom Count: 21
• Complexity: 36.8

Purity/Quality:

99% ^*data from raw suppliers

Hyaluronic Acid, Bovine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Metals, Inorganic Compounds
• Canonical SMILES: [OH-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2]
• Recent ClinicalTrials: Effects of Calcium Hydroxylapatite on Cellulite Dimples in the Buttocks
• Description: Calcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity. The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.
• Uses: Hydroxyapatite and tricalcium phosphate are bioactive ceramic materials and they find applications as bone grafts, fillers and coating material for metal implants. Prosthetic aid (artificial bone and teeth). In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.