Trimethylamine hydrochloride

Base Information

• Chemical Name: Trimethylamine hydrochloride
• CAS No.: 593-81-7
• Molecular Formula: C3H10ClN
• Molecular Weight: 95.5721
• Hs Code.: 2921.11 Oral rat LD50: 90 mg/kg
• European Community (EC) Number: 209-810-0
• NSC Number: 91484
• UNII: UW38SRM77K
• DSSTox Substance ID: DTXSID5027229
• Wikidata: Q27133385
• Metabolomics Workbench ID: 134803
• ChEMBL ID: CHEMBL450057
• Mol file: 593-81-7.mol

Synonyms:Methanamine,N,N-dimethyl-, hydrochloride (9CI);Trimethylamine, hydrochloride (8CI);Trimethylamine hydrochloric acid;Trimethylamine monohydrochloride;Trimethylammonium chloride;

Chemical Property of Trimethylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to slightly cream crystalline powder
• Vapor Pressure: 1720mmHg at 25°C
• Melting Point: 283-284 °C (dec.)(lit.)
• Refractive Index: 1.4413 (estimate)
• Boiling Point: 2.8oC at 760 mmHg
• PSA: 3.24000
• Density: 0.692g/cm3
• LogP: 0.97980
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: SOLUBLE
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 95.0501770
• Heavy Atom Count: 5
• Complexity: 8

Purity/Quality:

99% ^*data from raw suppliers

TrimethylamineMonohydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-38-36
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN(C)C.Cl
• Uses: In the manufacture of quaternary ammonium Compounds; as insect attractant; as warning agent for natural gas. Trimethylamine hydrochloride is used in the manufacture of quaternary ammonium compounds, as insect attractant. It is used as a raw material for the synthesis of choline chloride, quaternary ammonium compounds, ion exchange resins. It acts as cationic starch reagents, phase transfer catalyst, oil field chemicals, warning agent for natural gas and flotation agent. Trimethylamine hydrochloride is a precursor to prepare aluminium chloride- trimethylamine hydrochloride ionic liquid, which is commonly used in electrodeposition of aluminum wires. It is also used in the synthesis of trimethylamine gallane, trimethylamine-borane and azido-bridged perovskite-type metal-organic frameworks (MOFs).

Technology Process of Trimethylamine hydrochloride

There total 61 articles about Trimethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylamine-N-oxide (1184-78-7) + 1-chloro-2,4-dinitro-benzene (97-00-7) → 2,4-Dinitrophenol (51-28-5) + trimethylamine hydrochloride (593-81-7)

Guidance literature:

In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield: 97.0%

trimethylamine-N-oxide (1184-78-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-chloro-2,4-dinitro-benzene (97-00-7) → 2,4-Dinitrophenol (51-28-5) + trimethylamine hydrochloride (593-81-7)

Guidance literature:

for 24h; Ambient temperature;

Reference yield: 96.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → trimethylamine hydrochloride (593-81-7)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; With [1,4-bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; In methanol; at 25 ℃; under 30003 Torr; Autoclave;

With hydrogenchloride; In methanol; water; Reagent/catalyst;

upstream raw materials:

toluene

methyl 3-chloropropionate

trimethylamine

methanol

Downstream raw materials:

benzene-1,2-diol

choline chloride

choline picrate

trimethylammonium iodide

Refernces

• 1、 Ghosh, Pradip,Jacobi von Wangelin, Axel. "Manganese-Catalyzed Hydroborations with Broad Scope". supporting information. p. 16035 - 16043. Retrieved 2021/06/16.
• 2、 -. "DRUG ELUTING POLYMER COMPOSED OF BIODEGRADABLE POLYMERS APPLIED TO SURFACE OF MEDICAL DEVICE". . . Retrieved 2021/06/22.