2-Fluoro-3-methyl-5-aminopyridine

Base Information

• Chemical Name: 2-Fluoro-3-methyl-5-aminopyridine
• CAS No.: 186593-48-6
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.13
• Hs Code.: 2933399090
• Mol file: 186593-48-6.mol

Synonyms:3-Amino-6-fluoro-5-methylpyridine;5-Amino-2-fluoro-3-methylpyridine;6-Fluoro-5-methylpyridin-3-amine;

Chemical Property of 2-Fluoro-3-methyl-5-aminopyridine

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 275.545 °C at 760 mmHg
• Flash Point: 120.445 °C
• PSA: 38.91000
• Density: 1.196 g/cm³
• LogP: 1.69250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

6-Fluoro-5-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-37-38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-methyl-5-aminopyridine

There total 2 articles about 2-Fluoro-3-methyl-5-aminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-fluoro-3-methyl-5-nitropyridine (19346-46-4) → 5-amino-2-fluoro-3-methylpyridine (186593-48-6)

Guidance literature:

palladium-carbon; In ethanol;

Reference yield:

→ 5-amino-2-fluoro-3-methylpyridine (186593-48-6)

Guidance literature:

Reference yield: 83.0%

5-amino-2-fluoro-3-methylpyridine (186593-48-6) + C15H11ClN2O → 1-benzyl-3,4-dihydro-3-(6-fluoro-5-methylpyridin-3-yl)-4-iminoquinazolin-2(1H)-one

Guidance literature:

5-amino-2-fluoro-3-methylpyridine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

C₁₅H₁₁ClN₂O; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1002/anie.201610715

upstream raw materials:

2-fluoro-3-methyl-5-nitropyridine

Downstream raw materials:

2-fluoro-5-iodo-3-methylpyridine

Refernces

• 1、 -. "Preparation of 7a-heteroarylhexahydro-1H-pyrrolizines as cholinergic synaptic transmission modulators.". . . Retrieved 2008/06/13.