5-(Aminomethyl)-2-chloropyridine

Base Information

• Chemical Name: 5-(Aminomethyl)-2-chloropyridine
• CAS No.: 97004-04-1
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2933399090
• European Community (EC) Number: 619-497-6
• DSSTox Substance ID: DTXSID00427314
• Nikkaji Number: J1.078.411E
• Wikidata: Q72439327
• Mol file: 97004-04-1.mol

Synonyms:97004-04-1;(6-chloropyridin-3-yl)methanamine;5-(Aminomethyl)-2-chloropyridine;5-Aminomethyl-2-chloropyridine;2-Chloro-5-aminomethylpyridine;2-chloro-5-(aminomethyl)pyridine;3-PYRIDINEMETHANAMINE, 6-CHLORO-;C-(6-Chloro-pyridin-3-yl)-methylamine;6-chloro-3-pyridylmethylamine;1-(6-chloropyridin-3-yl)methanamine;MFCD00673153;(6-chloropyridin-3-yl)methylamine;6-Chloro-3-picolylamine;(6-chloro-3-pyridyl)methylamine;6-chloro-3pyridylmethylamine;2-chloro-5-pyridylmethylamine;SCHEMBL137992;3-aminomethyl-6-chloropyridine;6-chloro-3-aminomethylpyridine;6-chloro-3-pyri-dylmethylamine;2-chloro-5-aminomethyl-pyridine;3-aminomethyl-6-chloro-pyridine;5-aminomethyl-2-chloro-pyridine;6-Chloro-3-Pyridine Methylamine;DTXSID00427314;XPARFBOWIYMLMY-UHFFFAOYSA-N;(2-chloropyridin-5-yl)methylamine;5-(aminomethyl)-2- chloropyridine;(6-chloropyridin-3-yl)methaneamine;[(2-chloro-5-pyridyl)methyl]amine;BCP19252;AB8943;STK501622;[(6-chloropyridin-3-yl)methyl]amine;1-(6-chloropyridin-3-yl)methylamine;C-(6-Chloropyridin-3-yl)methylamine;6-CHLORO-3-PYRIDINEMETHANAMINE;AKOS005172026;AC-6002;AM81290;CS-W018542;PB17175;5-(Aminomethyl)-2-chloropyridine, 97%;SY030632;TS-01858;BB 0259965;FT-0611801;EN300-27823;Z247612574

Chemical Property of 5-(Aminomethyl)-2-chloropyridine

Chemical Property:

• Appearance/Colour: white to off-white crystal
• Vapor Pressure: 0.0175mmHg at 25°C
• Melting Point: 28-34 °C
• Refractive Index: 1.571
• Boiling Point: 254.2 °C at 760 mmHg
• PKA: 7.78±0.29(Predicted)
• Flash Point: 107.6 °C
• PSA: 38.91000
• Density: 1.244 g/cm³
• LogP: 1.89400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Hygroscopic
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

5-Aminomethyl-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, C
• Hazard Codes: T,C
• Statements: 25-37/38-41-43-34
• Safety Statements: 26-36/37/39-45-20

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1CN)Cl

Technology Process of 5-(Aminomethyl)-2-chloropyridine

There total 10 articles about 5-(Aminomethyl)-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3,5-tris[(2-chloropyridin-5-yl)methyl]-1,3,5-trihydrotriazine (1080018-12-7) → 5-(aminomethyl)-2-chloropyridine (97004-04-1)

Guidance literature:

1,3,5-tris[(2-chloropyridin-5-yl)methyl]-1,3,5-trihydrotriazine; With hydrogenchloride; water; In methanol; at 75 - 80 ℃; for 6h;

With sodium hydroxide; In methanol; chloroform; water;

Reference yield: 90.6%

→ 5-(aminomethyl)-2-chloropyridine (97004-04-1)

Guidance literature:

Reference yield: 87.0%

3-Aminomethylpyridine (3731-52-0) + phosgene (75-44-5) + sodium tungstate → 5-(aminomethyl)-2-chloropyridine (97004-04-1)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; trimethylamine; In hydrogenchloride; chloroform; water;

upstream raw materials:

6-chloronicotinonitrile

3-Aminomethylpyridine

phosgene

2-chloro-5-(chloromethyl)pyridine

Downstream raw materials:

2-chloro-5-acetaminomethylpyridine

N-(6-chloropyridin-3-yl)-benzamide

(6-chloropyridin-3-ylmethyl)carbamic acid tert-butyl ester

6-chloro-3-(cyclohexylamino-methyl)-pyridine

Refernces

• 1、 Dong, Guoqiang,Chen, Wei,Wang, Xia,Yang, Xinglin,Xu, Tianying,Wang, Pei,Zhang, Wannian,Rao, Yu,Miao, Chaoyu,Sheng, Chunquan. "Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors". . p. 7965 - 7983. Retrieved 2017/10/18.
• 2、 -. "Pyridine methylamino pyridine compound and method for preparing the same". . . Retrieved 2016/10/07.