Pyridine-3-boronic acid

Base Information Edit

Chemical Name:Pyridine-3-boronic acid
CAS No.:1692-25-7
Molecular Formula:C5H6BNO2
Molecular Weight:122.919
Hs Code.:29349990
DSSTox Substance ID:DTXSID30370268
Nikkaji Number:J806.559D
Wikipedia:3-pyridinylboronic acid
Wikidata:Q72504650
ChEMBL ID:CHEMBL3236605
Mol file:1692-25-7.mol

Synonyms:3-pyridineboronic acid

Suppliers and Price of Pyridine-3-boronic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
3-Pyridineboronic acid
1g
$ 403.00

Usbiological
3-Pyridineboronic Acid
2.5g
$ 403.00

TRC
3-PyridineboronicAcid
2g
$ 105.00

TCI Chemical
3-Pyridylboronic Acid (contains varying amounts of Anhydride)
25g
$ 198.00

TCI Chemical
3-Pyridylboronic Acid (contains varying amounts of Anhydride)
1g
$ 14.00

TCI Chemical
3-Pyridylboronic Acid (contains varying amounts of Anhydride)
5g
$ 40.00

Synthonix
Pyridine-3-boronic acid 97.0%
25g
$ 28.00

Synthonix
Pyridine-3-boronic acid 97.0%
10g
$ 20.00

Synthonix
Pyridine-3-boronic acid 97.0%
1g
$ 15.00

Synthonix
Pyridine-3-boronic acid 97.0%
5g
$ 17.00

Total 224 raw suppliers

Chemical Property of Pyridine-3-boronic acid Edit

Chemical Property:

Appearance/Colour:Light yellow powder
Vapor Pressure:0.000288mmHg at 25°C
Melting Point:>300 ºC
Refractive Index:1.534
Boiling Point:308.8 ºC at 760 mmHg
PKA:4.00±0.10(Predicted)
Flash Point:140.5 ºC
PSA：53.35000
Density:1.23 g/cm³
LogP:-1.23860
Storage Temp.:0-6°C
Solubility.:Slightly soluble in methanol.
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:123.0491586
Heavy Atom Count:9
Complexity:89

Purity/Quality:

99% ^*data from raw suppliers

3-Pyridineboronic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi,C,F
Hazard Codes:Xn,Xi,C,F
Statements: 36/37/38-22-34-11
Safety Statements: 36/37/39-3-26-45-16

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=CN=CC=C1)(O)O
Uses 3-Pyridylboronic acid is a reagent used for? ;Phosphine-free Suzuki-Miyaura cross-coupling reactions 1 ;Regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulation 2 ;N-arylation using copper acetylacetonate catalyst 3 ;Copper-mediated cyanation and regioselective cyanation of electron-rich benzenes 4 Reagent use in Preparation of ? ;New linear poly(phenylpyridyl) chains by Suzuki coupling 5 ;Oligopyridyl foldamers as mimics of a-helix twist 6 ;Many highly significant therapeutic enzymatic and kinase inhibitors and r suzuki reaction

Technology Process of Pyridine-3-boronic acid

There total 17 articles about Pyridine-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 109-72-8,29786-93-4
n-butyllithium

: 1692-25-7
3-pyridylboronic acid

Guidance literature:: 3-Bromopyridine; n-butyllithium; In toluene; at -50 ℃;

With Triisopropyl borate; In tetrahydrofuran; at -50 - -15 ℃;
DOI:10.1016/S0040-4039(02)00776-1

Reference yield: 75.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 1692-25-7
3-pyridylboronic acid

Guidance literature:: 3-Bromopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

With tris(trimethylsilyl)borate; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

With hydrogenchloride; at 0 ℃; pH=6 - 7;
DOI:10.1081/SCC-120016325

Reference yield: 73.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 5419-55-6
Triisopropyl borate

: 1692-25-7
3-pyridylboronic acid

Guidance literature:: 3-Bromopyridine; With n-butyllithium; In tetrahydrofuran; hexanes; toluene; at -60 - -50 ℃; for 0.75h;

Triisopropyl borate; With hydrogenchloride; In tetrahydrofuran; hexanes; water; toluene; at -50 - -15 ℃;