Propargylglycine

Base Information

• Chemical Name: Propargylglycine
• CAS No.: 58160-95-5
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.116
• Hs Code.: 2922499990
• Mol file: 58160-95-5.mol

Synonyms:Glycine,N-2-propynyl- (9CI);N-Propargylglycine;NSC 692226;Propargylglycine;

Chemical Property of Propargylglycine

Chemical Property:

• Melting Point: 243 °C (decomp)
• Boiling Point: 273.5 °C at 760 mmHg
• PKA: 2.18±0.10(Predicted)
• Flash Point: 119.2 °C
• PSA: 49.33000
• Density: 1.15 g/cm³
• LogP: -0.31530

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propargylglycine

There total 4 articles about Propargylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Iodoacetic acid (64-69-7) + Propargylamine (2450-71-7) → Nα-propargyl glycine (58160-95-5)

Guidance literature:

DOI:10.1002/mrc.1270130202

Reference yield: 65.0%

methyl-2-(prop-2-yn-1-ylamino)acetate (62490-40-8) → Nα-propargyl glycine (58160-95-5)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 1h;

DOI:10.1002/chem.200702024

Reference yield:

N-propargylglycine ethyl ester (57466-82-7) → Nα-propargyl glycine (58160-95-5)

Guidance literature:

With methanol; sodium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 0.666667h;

DOI:10.1055/s-0028-1083302

upstream raw materials:

Iodoacetic acid

Propargylamine

methyl-2-(prop-2-yn-1-ylamino)acetate

N-propargylglycine ethyl ester

Downstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-N-(propargyl)glycine

glycine

2-(2,6-Dichloro-benzoylamino)-pent-4-ynoic acid methyl ester

2-(2,6-dichlorobenzamido)pent-4-ynoic acid

Refernces

• 1、 Lin, Yutong,Malins, Lara R.,Malins, Lara R.. "An Electrochemical Approach to Designer Peptide α-Amides Inspired by α-Amidating Monooxygenase Enzymes". supporting information. p. 11811 - 11819. Retrieved 2021/08/16.
• 2、 Struthers, Harriet,Spingler, Bernhard,Mindt, Thomas L.,Schibli, Roger. " Click-to-chelate : Design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest". experimental part. p. 6173 - 6183. Retrieved 2009/05/27.