3-(4-Nitrophenyl)-beta-alanine

Base Information

• Chemical Name: 3-(4-Nitrophenyl)-beta-alanine
• CAS No.: 102308-62-3
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.189
• Mol file: 102308-62-3.mol

Synonyms:Hydrocinnamicacid, b-amino-p-nitro- (6CI);3-Amino-3-(4-nitrophenyl)propionic acid;3-(4-Nitrophenyl)-beta-alanine;

Chemical Property of 3-(4-Nitrophenyl)-beta-alanine

Chemical Property:

• Vapor Pressure: 1.81E-07mmHg at 25°C
• Melting Point: 226 °C (decomp)
• Refractive Index: 1.612
• Boiling Point: 410.347 °C at 760 mmHg
• PKA: 3.50±0.10(Predicted)
• Flash Point: 201.971 °C
• Density: 1.405 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-3-(4-nitrophenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Nitrophenyl)-beta-alanine

There total 11 articles about 3-(4-Nitrophenyl)-beta-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

malonic acid (141-82-2) + 4-nitrobenzaldehdye (555-16-8) → (RS)-3-Amino-3-(4-nitrophenyl)propanoic acid (102308-62-3,131690-58-9,131690-59-0,501030-96-2)

Guidance literature:

With ammonium acetate; In butan-1-ol; Reflux;

DOI:10.1016/j.ejmech.2018.07.005

Reference yield: 49.0%

p-nitrocinnamic acid (619-89-6) → (RS)-3-Amino-3-(4-nitrophenyl)propanoic acid (102308-62-3,131690-58-9,131690-59-0,501030-96-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium ethanolate; In water; Heating / reflux;

Reference yield: 40.0%

3-amino-3-(4-nitrophenyl)-2-carboxypropanoic acid (460039-81-0) → 4-nitro-trans-cinnamic acid (882-06-4) + 3-(4-nitrophenyl)-2-carboxy-2-propenoic acid (54267-71-9) + (RS)-3-Amino-3-(4-nitrophenyl)propanoic acid (102308-62-3,131690-58-9,131690-59-0,501030-96-2)

Guidance literature:

With ammonium acetate; malonic acid; In ethanol; for 48h; Heating;

DOI:10.1016/S0040-4020(02)00824-4

upstream raw materials:

ethyl 4-nitrocinnamate

ethanol

hydroxylamine

4-nitro-trans-cinnamic acid

Downstream raw materials:

C₁₇H₁₆N₂O₅

(R)-1-[3-benzamido-3-(4-nitrophenyl)propanamido]-3-methylbutylboronic acid

methyl 3-amino-3-(4-nitrophenyl)propanoate

(RS)-3-(9-fluorenylmethoxycarbonylamino)-3-(4-nitrophenyl)propanoic acid

Refernces

• 1、 Kashif, Muhammad,Chacón-Vargas, Karla Fabiola,López-Cedillo, Julio Cesar,Nogueda-Torres, Benjamín,Paz-González, Alma D.,Ramírez-Moreno, Esther,Agusti, Rosalia,Uhrig, Maria Laura,Reyes-Arellano, Alicia,Peralta-Cruz, Javier,Ashfaq, Muhammad,Rivera, Gildardo. "Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase". . p. 252 - 268. Retrieved 2018/07/14.
• 2、 -. "β-alanine derivates". Page/Page column 20. . Retrieved 2010/02/14.