2-Amino-3-(4-biphenylyl)propanoic acid

Base Information

• Chemical Name: 2-Amino-3-(4-biphenylyl)propanoic acid
• CAS No.: 76985-08-5
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID20457350
• Nikkaji Number: J1.213.375H
• Mol file: 76985-08-5.mol

Synonyms:76985-08-5;2-AMINO-3-(4-BIPHENYLYL)PROPANOIC ACID;4-Phenyl-DL-Phenylalanine;3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid;2-amino-3-(4-phenylphenyl)propanoic acid;2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID;SC-10914;MFCD03425234;H-4-PHENYL-PHE-OH;2-AMINO-3-(BIPHENYL-4-YL)PROPANOIC ACID;2-Acetamido-3-(4-biphenyl)propionic acid ethyl ester;DL-4-PHENYL-PHE-OH;H-beta-(4-Biphenylyl)-Ala-OH;H-Bip-OH;H-beta-(4-Biphenylyl)-D-Ala-OH;H-D-Bip-OH;3-(4-Biphenylyl)-D-alanine;MFCD01318879;(R)-2-amino-3-(biphenyl-4-yl)propanoic acid;SCHEMBL93494;ALPHA-AMINO-(1,1'-BIPHENYL)-4-PROPANOIC ACID;DTXSID20457350;BDA98508;AKOS000170983;AKOS022184250;AB08754;AB08756;AB14606;AM83473;CS-11320;SY015772;SY036178;alpha-Amino-1,1'-biphenyl-4-propionic acid;CS-0156431;FT-0641629;FT-0643526;FT-0643628;A50296;EN300-1869949;A838925;2-Amino-3-(4-biphenylyl)propanoic acid (H-DL-Bip-OH);2-AMINO-3-{[1,1'-BIPHENYL]-4-YL}PROPANOIC ACID;2-Amino-3-([1,1'-biphenyl]-4-yl)propanoic acid (non-preferred name)

Chemical Property of 2-Amino-3-(4-biphenylyl)propanoic acid

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 4.15E-08mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 428.6 °C at 760 mmHg
• Flash Point: 213 °C
• PSA: 63.32000
• Density: 1.19 g/cm³
• LogP: 3.00830
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CC(C(=O)O)N

Technology Process of 2-Amino-3-(4-biphenylyl)propanoic acid

There total 9 articles about 2-Amino-3-(4-biphenylyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H19NO3 → α-amino-(1,1'-biphenyl)-4-propanoic acid (76985-08-5,170080-13-4)

Guidance literature:

C₁₈H₁₉NO₃; With water; sodium hydroxide; at 5 ℃;

With bromine; sodium hydroxide; In water; at 80 ℃;

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → α-amino-(1,1'-biphenyl)-4-propanoic acid (76985-08-5,170080-13-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / Reflux

2.1: pyridine / toluene / Reflux

3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4.1: potassium hydroxide; ethanol / 20 °C

5.1: sodium hydroxide; water / 5 °C

5.2: 80 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; palladium on activated charcoal; water; hydrogen; potassium carbonate; potassium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

phenylboronic acid (98-80-6) → α-amino-(1,1'-biphenyl)-4-propanoic acid (76985-08-5,170080-13-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; N,N-dimethyl-formamide / Reflux

2.1: pyridine / toluene / Reflux

3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4.1: potassium hydroxide; ethanol / 20 °C

5.1: sodium hydroxide; water / 5 °C

5.2: 80 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; palladium on activated charcoal; water; hydrogen; potassium carbonate; potassium hydroxide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

p-phenylbenzyl bromide

4-bromo-benzaldehyde

phenylboronic acid

4-Phenylbenzaldehyde

Downstream raw materials:

methyl 3-([1,1‘-biphenyl]-4-yl)-2-aminopropanoate

(2E)-3-(1,1'-biphenyl-4-yl)acrylic acid

([1,1’-biphenyl]-4-yl)alanine

(S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid

Refernces