3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid

Base Information

• Chemical Name: 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
• CAS No.: 28860-96-0
• Molecular Formula: C₁₂H₁₈N₂O₄
• Molecular Weight: 254.286
• European Community (EC) Number: 618-965-7,608-270-7
• DSSTox Substance ID: DTXSID30546769
• Nikkaji Number: J1.632.602J
• Mol file: 28860-96-0.mol

Synonyms:28860-96-0;3-(3,4-dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;DL-3-(3,4-Dimethoxyphenyl)-2-methyl-2-hydrazine propionic acid;DL-3-(3,4-Dimethoxyphenyl)-2-methyl-2-diazanylpropionic acid;SCHEMBL1648711;DTXSID30546769;RPCRUCVXKKSQBD-UHFFFAOYSA-N;DL-3-(3,4-Dimethoxyphenyl)-2-methyl-2-hydrazinepropionic acidalanine;AKOS015889495;AC-19082;NS00003625;A819634;2-diazanyl-3-(3,4-dimethoxyphenyl)-2-methyl-propanoic acid;3-(3, 4-dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;3-(3,4-Dimethoxy-phenyl)-2-hydrazino-2-methyl-propionic Acid;DL-3-(3,4-Dimethoxyphenyl)-2-methyl-2-hydrazinepropionic acid alanine

Chemical Property of 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 450.953 °C at 760 mmHg
• PKA: 3.35±0.14(Predicted)
• Flash Point: 226.529 °C
• PSA: 93.81000
• Density: 1.208g/cm³
• LogP: 1.64410
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 254.12665706
• Heavy Atom Count: 18
• Complexity: 287

Purity/Quality:

99% ^*data from raw suppliers

(αS)-α-Hydrazinyl-3,4-dimethoxy-α-methyl-benzenepropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)OC)OC)(C(=O)O)NN
• Uses: (αS)-α-Hydrazinyl-3,4-dimethoxy-α-methyl-benzenepropanoic Acid is an intermediate used in the synthesis of (S)-(-)-Carbidopa (C175985), which is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.

Technology Process of 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid

There total 2 articles about 3-(3,4-Dimethoxyphenyl)-2-hydrazinyl-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(N'-Acetyl-hydrazino)-3-(3,4-dimethoxy-phenyl)-2-methyl-propionic acid ethyl ester (62969-39-5) → (R)-3-(3,4-Dimethoxy-phenyl)-2-hydrazino-2-methyl-propionic acid (28860-96-0)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/S0040-4039(00)75218-X

Reference yield:

→ 3-(3,4-dimethoxyphenyl)-2-hydrazino-2-methylpropionic acid (40248-77-9,28860-96-0)

Guidance literature:

7b, NaOCl;

DOI:10.1021/jo00813a024

upstream raw materials:

(R)-2-(N'-Acetyl-hydrazino)-3-(3,4-dimethoxy-phenyl)-2-methyl-propionic acid ethyl ester

Refernces