Omeprazole magnesium

Base Information

• Chemical Name: Omeprazole magnesium
• CAS No.: 161973-10-0
• Molecular Formula: C₃₄H₃₆MgN₆O₆S₂
• Molecular Weight: 713.133
• European Community (EC) Number: 620-470-6,627-029-7,630-398-7,669-839-3
• NCI Thesaurus Code: C29032,C65539,C66256
• RXCUI: 236486,283562,1294569
• Mol file: 161973-10-0.mol

Synonyms:Esomeprazole;Esomeprazole Magnesium;Esomeprazole Potassium;Esomeprazole Sodium;Esomeprazole Strontium;Esomeprazole Strontium Anhydrous;Nexium;Strontium, Esomeprazole

Chemical Property of Omeprazole magnesium

Chemical Property:

• Vapor Pressure: 2.35E-14mmHg at 25°C
• Boiling Point: 600 °C at 760 mmHg
• Flash Point: 316.7 °C
• PSA: 186.82000
• LogP: 6.78900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 10
• Exact Mass: 712.1988169
• Heavy Atom Count: 49
• Complexity: 993

Purity/Quality:

99%min , ^*data from raw suppliers

Esomeprazole Magnesium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
• Recent ClinicalTrials: High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
• Recent EU Clinical Trials: 'A Phase III Study to Assess the Efficacy and Safety of NEXIUM for Maintenance of Healing of Erosive Esophagitis in Pediatric Patients 1 to 11 Years of Age'
• Indications: Esomeprazole, a proton-pump inhibitor (PPI), is the S-isomer of omeprazole. Esomeprazole has FDA-approved labeling for use in the treatment of symptomatic gastroesophageal reflux disease (GERD), including healing and maintenance of healing of erosive esophagitis and as part of a triple-drug regimen for Helicobacter pylori infection.
• Uses: Antiulcerative S-Form of Omeprazole. Gastric proton-pump inhibitor.

Technology Process of Omeprazole magnesium

There total 5 articles about Omeprazole magnesium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

esomeprazole piperidine salt (1306616-22-7) + magnesium chloride (7786-30-3) → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

In methanol; acetone; at 20 ℃; for 2.5h;

Reference yield:

(S)-(-)-binol-S-omeprazole inclusion complex (272776-12-2) → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

(S)-(-)-binol-S-omeprazole inclusion complex; With sodium hydroxide; In Isopropyl acetate; water; at 20 ℃; pH=12;

With magnesium chloride; In methanol; water; at 20 - 25 ℃; for 4h; Product distribution / selectivity;

Reference yield:

esomeprazole sodium salt → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

esomeprazole sodium salt; In water; at 1 - 25 ℃; for 1h;

With magnesium sulfate heptahydrate; In water; at 1 - 7 ℃; for 2.5h; Product distribution / selectivity;

upstream raw materials:

(S)-(-)-binol-S-omeprazole inclusion complex

omeprazole

omeprazole sulfide

esomeprazole piperidine salt

Downstream raw materials:

(S)-(-)-binol-S-omeprazole inclusion complex

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF ESOMEPRAZOLE". Page/Page column 12-13. . Retrieved 2010/07/09.