Thiophene-2,3-dicarboxylic acid

Base Information

• Chemical Name: Thiophene-2,3-dicarboxylic acid
• CAS No.: 71189-23-6
• Molecular Formula: C₄H₂N₂OS
• Molecular Weight: 126.139
• Hs Code.: 2934100090
• Mol file: 71189-23-6.mol

Synonyms:2-Thiazolylisocyanate

Chemical Property of Thiophene-2,3-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 0.206mmHg at 25°C
• Boiling Point: 216 ºC
• PKA: 1.27±0.10(Predicted)
• Flash Point: 85 ºC
• PSA: 102.84000
• Density: 1.41
• LogP: 1.14450

Purity/Quality:

99% ^*data from raw suppliers

2-Isocyanatothiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiophene-2,3-dicarboxylic acid

There total 1 articles about Thiophene-2,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thiazolylamine (96-50-4) + bis(trichloromethyl) carbonate (32315-10-9) → Thiazol-2-ylisocyanate (71189-23-6)

Guidance literature:

With triethylamine; In toluene;

Reference yield:

Thiazol-2-ylisocyanate (71189-23-6) + 3-aminophenylboronic acid pinacolate (210907-84-9) → C16H20BN3O3S

Guidance literature:

In dichloromethane; for 0.333333h;

DOI:10.1016/j.ejmech.2015.08.045

Reference yield:

Thiazol-2-ylisocyanate (71189-23-6) + 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) → N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N'-(1,3-thiazol-2-yl)urea

Guidance literature:

In dichloromethane; at 24 ℃; for 1h;

DOI:10.1016/j.bmcl.2006.04.068

upstream raw materials:

2-thiazolylamine

bis(trichloromethyl) carbonate

Refernces

• 1、 Shan, Yuanyuan,Gao, Hongping,Shao, Xiaowei,Wang, Jinfeng,Pan, Xiaoyan,Zhang, Jie. "Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approach". . p. 80 - 90. Retrieved 2015/09/15.
• 2、 -. "Inhibitors of protein isoprenyl transferases". . . Retrieved 2008/06/13.