3,5-Dimethylphenylhydrazine hydrochloride

Base Information

• Chemical Name: 3,5-Dimethylphenylhydrazine hydrochloride
• CAS No.: 60481-36-9
• Molecular Formula: C8H12N2^.HCl
• Molecular Weight: 172.658
• Hs Code.: 29280000
• European Community (EC) Number: 678-905-0
• DSSTox Substance ID: DTXSID50505732
• Mol file: 60481-36-9.mol

Synonyms:3,5-Dimethylphenylhydrazine hydrochloride;60481-36-9;(3,5-dimethylphenyl)hydrazine hydrochloride;3,5-Dimethylphenylhydrazine, HCl;(3,5-dimethylphenyl)hydrazine;hydrochloride;3,5-Dimethylphenylhydrazine HCl;3,5-dimethylphenylhydrazine;MFCD00052269;Hydrazine, (3,5-dimethylphenyl)-, monohydrochloride;SCHEMBL1761294;DTXSID50505732;RSBQANBNDXZFIY-UHFFFAOYSA-N;(3,5-dimethylphenyl)hydrazine HCl;AKOS001476035;AC-1403;CS-W010766;GS-3454;SY004229;A8439;AM20050044;FT-0640693;EN300-07656;1-(3,5-dimethylphenyl) hydrazine hydrochloride;I10047;Z56951220;(3,5-Dimethylphenyl)hydrazine--hydrogen chloride (1/1);F0001-1585

Chemical Property of 3,5-Dimethylphenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.0259mmHg at 25°C
• Melting Point: 180 °C
• Boiling Point: 247.3 °C at 760 mmHg
• Flash Point: 118.6 °C
• PSA: 38.05000
• LogP: 3.16430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 172.0767261
• Heavy Atom Count: 11
• Complexity: 93.4

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dimethylphenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-45-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1)NN)C.Cl
• Uses: 3,5-Dimethylphenylhydrazine hydrochloride participates inFischer indole synthesis protocol in biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant mycobacterium tuberculosis strains.

Technology Process of 3,5-Dimethylphenylhydrazine hydrochloride

There total 2 articles about 3,5-Dimethylphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.22%

3,5-dimethylaminoaniline (108-69-0) → (3,5-dimethylphenyl)hydrazine hydrochloride (60481-36-9)

Guidance literature:

3,5-dimethylaminoaniline; With hydrogenchloride; In water; at 25 - 35 ℃; for 0.333333h;

With sodium nitrite; In water; at -5 - 0 ℃;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at -5 - 35 ℃;

Reference yield: 75.0%

5-bromo-1,3-xylene (556-96-7) → (3,5-dimethylphenyl)hydrazine hydrochloride (60481-36-9)

Guidance literature:

5-bromo-1,3-xylene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + (3,5-dimethylphenyl)hydrazine hydrochloride (60481-36-9) → tert-butyl 2-(3,5-dimethylphenyl)hydrazinecarboxylate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/c6nj03718f

upstream raw materials:

3,5-dimethylaminoaniline

5-bromo-1,3-xylene

Downstream raw materials:

methyl 2-(3,5-dimethylphenylhydrazono)-2-phenylacetate

3-{1-[(3,5-Dimethyl-phenyl)-hydrazono]-ethyl}-4-hydroxy-chromen-2-one

5-amino-1-(3,5-dimethylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

1-(3,5-Dimethyl-phenyl)-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one

Refernces

• 1、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.
• 2、 -. "NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS". Page/Page column 31. . Retrieved 2010/12/29.