4-Piperidinylpiperidine dihydrochloride

Base Information

• Chemical Name: 4-Piperidinylpiperidine dihydrochloride
• CAS No.: 172281-92-4
• Molecular Formula: C₁₀H₂₀N₂*(x)ClH
• Molecular Weight: 241.2
• Hs Code.: 2933399090
• Mol file: 172281-92-4.mol

Synonyms:4-Piperidinopiperidine hydrochloride;1,4'-Bipiperidine,monohydrochloride (9CI);

Chemical Property of 4-Piperidinylpiperidine dihydrochloride

Chemical Property:

• Boiling Point: 284.1 °C at 760 mmHg
• Flash Point: 125.6 °C
• PSA: 15.27000
• LogP: 3.09500
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% or more ^*data from raw suppliers

[1,4']Bipiperidinylhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinylpiperidine dihydrochloride

There total 3 articles about 4-Piperidinylpiperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1,4’-bipiperidine-1’-carboxylate (125541-12-0) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1038/onc.2014.225

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1038/onc.2014.225

Reference yield:

piperidine (110-89-4) → 1,4'-bipiperidine hydrochloride (172281-92-4,4876-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1038/onc.2014.225

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 1,4’-bipiperidine-1’-carboxylate

piperidine

Refernces