2-Bromo-5-chlorobenzaldehyde

Base Information

• Chemical Name: 2-Bromo-5-chlorobenzaldehyde
• CAS No.: 84459-33-6
• Molecular Formula: C7H4BrClO
• Molecular Weight: 219.465
• Hs Code.: 2913000090
• Mol file: 84459-33-6.mol

Synonyms:2-Bromo-4-chloro benzaldehyde;

Chemical Property of 2-Bromo-5-chlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.0096mmHg at 25°C
• Melting Point: 69.0 to 73.0 °C
• Refractive Index: 1.623
• Boiling Point: 264.6 °C at 760 mmHg
• Flash Point: 113.8 °C
• PSA: 17.07000
• Density: 1.698 g/cm³
• LogP: 2.91500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-4-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-chlorobenzaldehyde

There total 12 articles about 2-Bromo-5-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C15H20BrClN2O2 → 2-bromo-4-chlorobenzaldehyde (84459-33-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 10 - 30 ℃;

Reference yield: 85.0%

(2-bromo-4-chloro-phenyl)methanol (143888-84-0) → 2-bromo-4-chlorobenzaldehyde (84459-33-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h;

Reference yield:

2-bromo-4-chloro-N-methoxy-N-methylbenzamide → 2-bromo-4-chlorobenzaldehyde (84459-33-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 1h;

upstream raw materials:

(2-bromo-4-chloro-phenyl)methanol

2-bromo-4-chloro-1-(dibromomethyl)benzene

2-bromo-4-chlorobenzoic acid

4-Cyanochlorobenzene

Downstream raw materials:

2-bromo-4-chloro-1-[2-nitroethenyl]benzene

(2-bromo-4-chloro-phenyl)methanol

1-bromo-5-chloro-2-(2,2-dibromovinyl)benzene

1-bromo-2-[(Z)-2-bromovinyl]-5-chlorobenzene

Refernces

• 1、 -. "FACTOR XIa INHIBITORS". . . Retrieved 2017/05/21.
• 2、 -. "FACTOR XIa INHIBITORS". . . Retrieved 2016/11/02.