2-Bromobenzene-1,3-dialdehyde

Base Information

• Chemical Name: 2-Bromobenzene-1,3-dialdehyde
• CAS No.: 79839-49-9
• Molecular Formula: C8H5BrO2
• Molecular Weight: 213.03
• Hs Code.: 2913000090
• Mol file: 79839-49-9.mol

Synonyms:1-Bromo-2,6-diformylbenzene;2-Bromobenzene-1,3-dialdehyde;2-Bromobenzene-1,3-dicarboxaldehyde;2-Bromoisophthaldehyde;

Chemical Property of 2-Bromobenzene-1,3-dialdehyde

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 139 °C
• Refractive Index: 1.657
• Boiling Point: 298.02 °C at 760 mmHg
• Flash Point: 121.394 °C
• PSA: 34.14000
• Density: 1.652 g/cm³
• LogP: 2.07410
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromoisophthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used in the preparation of paclitaxel-mimicking alkaloids with anticancer activity.

Technology Process of 2-Bromobenzene-1,3-dialdehyde

There total 7 articles about 2-Bromobenzene-1,3-dialdehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-1,3-bis(bromomethyl)benzene (25006-88-6) → 2-bromoisophthalaldehyde (79839-49-9)

Guidance literature:

With formic acid; Heating;

DOI:10.1002/jlcr.1267

Reference yield: 94.0%

1,3-bis(dibromomethyl)-2-bromobenzene (135590-51-1) → 2-bromoisophthalaldehyde (79839-49-9)

Guidance literature:

With formic acid; for 12h; Heating;

DOI:10.1021/jo030348n

Reference yield: 92.4%

2,6-bis(hydroxymethyl)bromobenzene (59346-22-4) → 2-bromoisophthalaldehyde (79839-49-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; Celite;

DOI:10.1016/j.tet.2009.08.026

upstream raw materials:

2-Bromo-m-xylene

1,3-bis(dibromomethyl)-2-bromobenzene

2-bromo-1,3-bis(bromomethyl)benzene

1,3-bis(diacetoxymethyl)-2-bromo-benzene

Downstream raw materials:

2-(2-methoxynaphthalen-6-yl)benzene-1,3-dialdehyde

1,2-bis(2,6-diformylphenylthio)ethane

2-bromo-3-(1,3-dioxolan-2-yl)benzaldehyde

2-bromo-1,3-diethenylbenzene

Refernces

• 1、 Feng, Jie,Lu, Guoping,Lv, Meifang,Cai, Chun. "Palladium catalyzed direct C-2 arylation of indoles". . p. 28 - 31. Retrieved 2014/04/17.
• 2、 -. "BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS". . . Retrieved 2011/04/13.