N,N-dimethyl-2-piperazin-1-yl-acetamide

Base Information

• Chemical Name: N,N-dimethyl-2-piperazin-1-yl-acetamide
• CAS No.: 39890-43-2
• Molecular Formula: C8H17N3O
• Molecular Weight: 171.242
• Hs Code.: 2933599090
• European Community (EC) Number: 673-693-6
• DSSTox Substance ID: DTXSID50374425
• Wikidata: Q82163015
• Mol file: 39890-43-2.mol

Synonyms:39890-43-2;N,N-dimethyl-2-piperazin-1-yl-acetamide;N,N-dimethyl-2-(piperazin-1-yl)acetamide;N,N-dimethyl-2-piperazin-1-ylacetamide;1-Piperazineacetamide, N,N-dimethyl-;N,N-DIMETHYLAMIDE CARBONYLMETHYL PIPERAZINE;N,N-dimethyl-2-piperazine-1-yl-acetamide;SCHEMBL5863;PIPERAZINO-ACETIC ACID-N,N-DIMETHYLAMIDE;(N,N-DIMETHYLAMIDECARBONYLMETHYL)PIPERAZINE;DTXSID50374425;JJEMPZXXGBIJIX-UHFFFAOYSA-N;HMS1746P09;N,N-Dimethyl-1-piperazineacetamide;N,N-dimethyl-2-piperazinoacetamide;BBL029150;MFCD01075232;STK711149;AKOS000264375;PS-3124;Piperazine acetic acid N,N-dimethylamide;piperazino-acetic acid N,N-dimethylamide;1-(N,N-dimethylcarbamoylmethyl)piperazine;BP-10149;N,N-dimethyl-2-(1-piperazinyl)acetamide;BB 0216425;CS-0206937;FT-0639585;EN300-12361;N,N-dimethyl-2-piperazin-1-yl-acetamide, AldrichCPR;Z85938655

Chemical Property of N,N-dimethyl-2-piperazin-1-yl-acetamide

Chemical Property:

• Vapor Pressure: 0.00293mmHg at 25°C
• Boiling Point: 284.7 °C at 760 mmHg
• PKA: 8.98±0.10(Predicted)
• Flash Point: 126 °C
• PSA: 35.58000
• Density: 1.016 g/cm³
• LogP: -0.75350
• Storage Temp.: 2-8°C
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 171.137162174
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Dimethyl-2-(piperazin-1-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)CN1CCNCC1

Technology Process of N,N-dimethyl-2-piperazin-1-yl-acetamide

There total 1 articles about N,N-dimethyl-2-piperazin-1-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N,N-dimethyl-2-piperazin-1-yl-acetamide (39890-43-2)

Guidance literature:

Piperazin, Dimethylchloracetamid;

Reference yield: 89.6%

3,4-dinitrobenzyl methanesulphonate + N,N-dimethyl-2-piperazin-1-yl-acetamide (39890-43-2) → 2-(4-(3,4-dinitrobenzyl)piperazin-1-yl)-N,N-dimethylacetamide

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 55.0%

{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid (1404529-09-4) + N,N-dimethyl-2-piperazin-1-yl-acetamide (39890-43-2) → [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-chloro-1-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:

{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid; N,N-dimethyl-2-piperazin-1-yl-acetamide; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 20 ℃; for 20h;

With hydrogenchloride; In diethyl ether; dichloromethane; acetone;

DOI:10.1021/jm500588w

Downstream raw materials:

2-(4-{3-[2-(2,4-dichlorophenyl)-ethoxy]-4-methoxy-benzoyl}-piperazin-1-yl)-N,N-dimethyl-acetamide

(4-{1-[4-((4aR,10bR)-8,9-dimethoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-6-yl)-phenyl]-methanoyl}-piperazin-1-yl)-dimethylamino-ethanone

2-[4-(4-bromo-benzenesulfonyl)-piperazin-1-yl]-N,N-dimethyl-acetamide

2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[2-(4-{N,N-dimethylaminocarbonylmethyl}piperazin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole