trans-(1R,2R)-2-Aminocyclopentanol hydrochloride

Base Information

• Chemical Name: trans-(1R,2R)-2-Aminocyclopentanol hydrochloride
• CAS No.: 31775-67-4
• Molecular Formula: C5H11NO^.HCl
• Molecular Weight: 137.609
• Hs Code.: 2922199090
• Mol file: 31775-67-4.mol

Synonyms:Cyclopentanol,2-amino-, hydrochloride, (1R,2R)-rel- (9CI);Cyclopentanol, 2-amino-,hydrochloride, trans- (8CI);trans-1-Hydroxycyclopentan-2-aminium chloride;trans-2-Aminocyclopentanol hydrochloride;

Chemical Property of trans-(1R,2R)-2-Aminocyclopentanol hydrochloride

Chemical Property:

• Melting Point: 191-196 °C(lit.)
• Boiling Point: 220.9 °C at 760 mmHg
• Flash Point: 87.4 °C
• PSA: 46.25000
• LogP: 1.36080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

trans-2-Aminocyclopentanol hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1R,2R)-2-Aminocyclopentanol hydrochloride is a useful research chemical compound.

Technology Process of trans-(1R,2R)-2-Aminocyclopentanol hydrochloride

There total 7 articles about trans-(1R,2R)-2-Aminocyclopentanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(±)-trans-2-azidocyclopentanol (88807-02-7) → (±)-trans-2-aminocyclopentanol hydrochloride (31775-67-4)

Guidance literature:

(±)-trans-2-azidocyclopentanol; With hydrogen; 10% palladium on activated carbon; In ethyl acetate; at 23 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate;

Reference yield:

Cyclopentene oxide (285-67-6) → (±)-trans-2-aminocyclopentanol hydrochloride (31775-67-4)

Guidance literature:

With ammonia; water; at 110 ℃;

DOI:10.1021/ja01161a089

Reference yield:

(1R,2R)-2-Isocyano-cyclopentanol (83152-98-1) → (±)-trans-2-aminocyclopentanol hydrochloride (31775-67-4)

Guidance literature:

hydrolysis;

DOI:10.1021/ja00385a078

upstream raw materials:

(+/-)-2-(4-nitro-phenyl)-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentoxazole

trans-2-aminocyclopentanol

(+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cyclopentylamide)

Cyclopentene oxide

Downstream raw materials:

(±)-trans-2-(dimethylamino)cyclopentanol

Refernces

• 1、 Gassman, Paul G.,Guggenheim, Thomas L.. "Opening of Epoxides with Trimethylsilyl Cyanide To Produce β-Hydroxy Isonitriles. A General Synthesis of Oxazolines and β-Amino Alcohols". . p. 5849 - 5850. Retrieved 2007/10/02.