(S)-3-Aminopentanoic acid

Base Information

• Chemical Name: (S)-3-Aminopentanoic acid
• CAS No.: 14389-77-6
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 2922499990
• Mol file: 14389-77-6.mol

Synonyms:Pentanoicacid, 3-amino-, (S)-;Valeric acid, 3-amino-, (S)-(+)- (8CI);

Chemical Property of (S)-3-Aminopentanoic acid

Chemical Property:

• Appearance/Colour: Colorless to pale yellow liquid
• Vapor Pressure: 0.0238mmHg at 25°C
• Refractive Index: 1.463
• Boiling Point: 230.1 °C at 760 mmHg
• Flash Point: 93 °C
• PSA: 63.32000
• Density: 1.067 g/cm³
• LogP: 0.89870
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Aminopentanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Aminopentanoic acid

There total 6 articles about (S)-3-Aminopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-aminopentanoic acid ethyl ester (78221-21-3) → (R)-β-aminopentanoic acid (131347-76-7) + (3S)-3-aminopentanoic acid (14389-77-6)

Guidance literature:

With hydrogenchloride; In water; at 70 ℃; for 2h; pH=2; Overall yield = 49percent;

DOI:10.1002/cctc.202100503

Reference yield:

Methyl (E)-2-pentenoate (15790-87-1,818-59-7,15790-88-2) → (R)-β-aminopentanoic acid (131347-76-7) + (3S)-3-aminopentanoic acid (14389-77-6)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

(S)-3-(Toluene-4-sulfonylamino)-pentanoic acid ethyl ester → (3S)-3-aminopentanoic acid (14389-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / methanol; H₂O / 25 °C

2: 1) PhOH, 47percent aq. HBr, 2) epoxypropane / 1) reflux

With hydrogen bromide; potassium carbonate; methyloxirane; phenol; In methanol; water;

DOI:10.1016/S0040-4039(00)77503-4

upstream raw materials:

Methyl (E)-2-pentenoate

ethyl (S)-3-acetamidopentanoate

3-aminopentanoic acid ethyl ester

Downstream raw materials:

(S)-3-amino-pentanoic acid methyl ester

6-(S)-ethyl-1-(4-fluoro-benzyl)-4-hydroxy-3-(1-methyl-7-nitro-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5,6-dihydro-1H-pyridin-2-one

3-(7-amino-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-6-(S)-ethyl-1-(4-fluoro-benzyl)-4-hydroxy-5,6-dihydro-1H-pyridin-2-one

(S)-3-(4-fluoro-benzylamino)-pentanoic acid methyl ester

Refernces

• 1、 Wang, Yingang,Feng, Jinhui,Dong, Wenyue,Chen, Xi,Yao, Peiyuan,Wu, Qiaqing,Zhu, Dunming. "Improving Catalytic Activity and Reversing Enantio-Specificity of ω-Transaminase by Semi-Rational Engineering en Route to Chiral Bulky β-Amino Esters". . p. 3396 - 3400. Retrieved 2021/06/21.
• 2、 Jefford,Wang. "An enantiospecific synthesis of β-amino acids". . p. 1111 - 1114. Retrieved 2007/10/02.