6-Bromoquinazoline

Base Information

• Chemical Name: 6-Bromoquinazoline
• CAS No.: 89892-21-7
• Molecular Formula: C8H5 Br N2
• Molecular Weight: 209.045
• Hs Code.: 2933990090
• Mol file: 89892-21-7.mol

Synonyms:6-Bromoquinazoline

Chemical Property of 6-Bromoquinazoline

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 136-138 °C
• Refractive Index: 1.685
• Boiling Point: 304.254 °C at 760 mmHg
• PKA: 3.61±0.26(Predicted)
• Flash Point: 137.808 °C
• PSA: 25.78000
• Density: 1.657 g/cm³
• LogP: 2.39230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Bromoquinazoline ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromoquinazoline is a reagent for structure-based design of biaryl mannoside fimH inhibitors for use in urinary infection treatment.

Technology Process of 6-Bromoquinazoline

There total 2 articles about 6-Bromoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinazoline (253-82-7) → 6-bromoquinazoline (89892-21-7)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; In trifluoroacetic acid; at 20 ℃; for 17h;

Reference yield:

→ 6-bromoquinazoline (89892-21-7)

Guidance literature:

5-Brom-2-nitro-1-benzol, Zink-Pulver, wss. Eg.;

Reference yield: 87.9%

6-bromoquinazoline (89892-21-7) + bis(pinacol)diborane (73183-34-3) → 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline (1375301-92-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,2-dimethoxyethane; at 80 ℃; for 4h; Inert atmosphere;

upstream raw materials:

quinazoline

Downstream raw materials:

N-(2-chloro-5-(quinazolin-6-yl)pyridin-3-yl)benzenesulfonamide

N-(2-chloro-5-(quinazolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

4-(quinazolin-6-yl)phenyl α-D-mannopyranoside

6-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)thio)phenyl)quinazoline

Refernces

• 1、 -. "Trifluoromethyl substituted benzamides as kinase inhibitors". Page/Page column 20. . Retrieved 2008/06/13.