4-Bromo-3-(trifluoromethyl)phenol

Base Information

• Chemical Name: 4-Bromo-3-(trifluoromethyl)phenol
• CAS No.: 320-49-0
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.007
• Hs Code.: 2908199090
• Mol file: 320-49-0.mol

Synonyms:2-Bromo-5-hydroxybenzotrifluoride;Phenol, 4-bromo-3-(trifluoromethyl)-;Jsp005943;MolPort-001-775-255;ZINC02384140;3-Trifluoromethyl-4-bromo phenol;

Chemical Property of 4-Bromo-3-(trifluoromethyl)phenol

Chemical Property:

• Vapor Pressure: 1.24mmHg at 25°C
• Melting Point: 44-46 °C
• Refractive Index: 1.47
• Boiling Point: 234.852 °C at 760 mmHg
• PKA: 8.39±0.18(Predicted)
• Flash Point: 95.835 °C
• PSA: 20.23000
• Density: 1.752 g/cm³
• LogP: 3.17350
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-3-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-3-(trifluoromethyl)phenol

There total 3 articles about 4-Bromo-3-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-Trifluoromethylphenol (98-17-9) → 3-trifluoromethyl-4-bromophenol (320-49-0)

Guidance literature:

With acetic acid; potassium bromide; In water; acetic acid; at 35 ℃; regioselective reaction;

DOI:10.3390/molecules25040914

Reference yield:

concentrated H2 SO4 + sulfuric acid (7664-93-9) + 4-bromo-3-(trifluoromethyl)aniline (393-36-2) → 3-trifluoromethyl-4-bromophenol (320-49-0)

Guidance literature:

With magnesium sulfate; In water; sodium nitrite;

Reference yield:

4-bromo-3-(trifluoromethyl)aniline (393-36-2) → 3-trifluoromethyl-4-bromophenol (320-49-0)

Guidance literature:

With sulfuric acid; sodium nitrite; anschliessendes Erwaermen mit wss. H₂SO₄ unter Einleiten von Wasserdampf;

DOI:10.1021/ja01147a139

upstream raw materials:

4-bromo-3-(trifluoromethyl)aniline

3-Trifluoromethylphenol

sulfuric acid

Downstream raw materials:

3-trifluoromethyl-4-bromo-1-methoxy-benzene

4-[4-bromo-3-(trifluoromethyl)phenoxy]furo[3,2-c]pyridine

Refernces

• 1、 -. "NEW THIADIAZOLE DERIVATIVES". Page/Page column 80. . Retrieved 2011/04/24.
• 2、 -. "Pesticidal pyrimidine compounds". . . Retrieved 2008/06/13.