5-Carboxytetramethylrhodamine succinimidyl ester

Base Information

• Chemical Name: 5-Carboxytetramethylrhodamine succinimidyl ester
• CAS No.: 150810-68-7
• Molecular Formula: C29H25N3O7
• Molecular Weight: 527.53
• Hs Code.: 32049010
• DSSTox Substance ID: DTXSID10376329
• Wikidata: Q27902945
• Mol file: 150810-68-7.mol

Synonyms:5-carboxytetramethylrhodamine succinimidyl ester;TAMRA cpd

Chemical Property of 5-Carboxytetramethylrhodamine succinimidyl ester

Chemical Property:

• PSA: 123.43000
• LogP: 3.18830
• Storage Temp.: ?20°C
• Solubility.: DMF: soluble
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 527.16925015
• Heavy Atom Count: 39
• Complexity: 1140

Purity/Quality:

95%min ^*data from raw suppliers

5-CarboxytetramethylrhodamineSuccinimidylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](C)C)C=C3O2)C4=C(C=C(C=C4)C(=O)ON5C(=O)CCC5=O)C(=O)[O-]
• Description: 5-Carboxytetramethylrhodamine succinimidyl ester (5-TAMRA-SE) is an amine-reactive fluorescent probe. It has been used in double site-directed peptide modification to label proteinase substrates for use in FRET assays. It quenches lucifer yellow CH fluorescence by greater than 90% in uncleaved proteinase substrates, which allows for the detection of enzyme-cleaved substrates by an increase in fluorescence intensity. It has also been used in the synthesis of fluorescent derivatives of a variety of compounds, including the antibiotic ampicillin , nucleotide diphosphate uridine-5’-diphosphate (UDP; ), and the progesterone receptor antagonist RU486 (mifepristone; ). 5-TAMRA-SE displays excitation maxima ranging from 540 to 560 nm and an emission maximum of 580 nm.
• Uses: Amine-reactive form of 5-carboxytetramethylrhodamine single isomer. Amine-Reactive Fluorescent Probe for labeling of DNA and RNA