(S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

Base Information

• Chemical Name: (S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester
• CAS No.: 148797-37-9
• Molecular Formula: C₂₄H₃₀N₃O₁₁P
• Molecular Weight: 567.489
• Mol file: 148797-37-9.mol

Synonyms:(S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

Chemical Property of (S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Boc-Abu (34306-42-8) + di-p-nitrobenzyl 1-hydroxymethanephosphonate (119552-95-3) → (S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester (148797-37-9)

Guidance literature:

With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

(S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester (148797-37-9) → (S)-2-Benzyloxycarbonylamino-4-{(S)-1-[bis-(4-nitro-benzyloxy)-phosphorylmethoxycarbonyl]-propylcarbamoyl}-butyric acid benzyl ester (148797-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / Ambient temperature

2: ethyl acetate; diethyl ether / 2 h / cooled

3: triethylamine / 1) methylene dichloride, -5 deg C, 30 min, 2) methylene dichloride, r.t., overnight

With triethylamine; In diethyl ether; ethyl acetate;

Reference yield:

(S)-2-tert-Butoxycarbonylamino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester (148797-37-9) → (S)-2-Amino-butyric acid bis-(4-nitro-benzyloxy)-phosphorylmethyl ester; compound with oxalic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / Ambient temperature

2: ethyl acetate; diethyl ether / 2 h / cooled

In diethyl ether; ethyl acetate;

upstream raw materials:

Boc-Abu

di-p-nitrobenzyl 1-hydroxymethanephosphonate

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-4-{(S)-1-[bis-(4-nitro-benzyloxy)-phosphorylmethoxycarbonyl]-propylcarbamoyl}-butyric acid benzyl ester

Refernces