5-Chloro-8-methoxyl-2-tetralone

Base Information

• Chemical Name: 5-Chloro-8-methoxyl-2-tetralone
• CAS No.: 136949-71-8
• Molecular Formula: C₁₁H₁₁ClO₂
• Molecular Weight: 210.66
• Mol file: 136949-71-8.mol

Synonyms:5-Chloro-8-methoxyl-3,4-dihydro-1H-naphthalen-2-one

Chemical Property of 5-Chloro-8-methoxyl-2-tetralone

Chemical Property:

• PSA: 26.30000
• LogP: 2.40640

Purity/Quality:

98% ^*data from raw suppliers

5-Chloro-8-methoxyl-2-tetralone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-8-methoxyl-2-tetralone

There total 1 articles about 5-Chloro-8-methoxyl-2-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-7-methoxy-3,8a-dihydro-2H-azulen-1-one → 1,2,3,4-tetrahydro-5-methoxy-8-chloro-2(1H)-naphthalenone (136949-71-8)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Ambient temperature;

DOI:10.1021/jm00020a021

Reference yield:

1,2,3,4-tetrahydro-5-methoxy-8-chloro-2(1H)-naphthalenone (136949-71-8) → (2-Aminomethyl-8-chloro-5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzyl-amine (1027653-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH / toluene / 2 h / Heating

2: ZnI₂ / CH₂Cl₂ / 20 °C

3: LiAlH₄ / tetrahydrofuran / 24 h

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; zinc(II) iodide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm00020a021

Reference yield:

1,2,3,4-tetrahydro-5-methoxy-8-chloro-2(1H)-naphthalenone (136949-71-8) → 2-Benzylamino-8-chloro-5-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile (1028273-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / toluene / 2 h / Heating

2: ZnI₂ / CH₂Cl₂ / 20 °C

With toluene-4-sulfonic acid; zinc(II) iodide; In dichloromethane; toluene;

DOI:10.1021/jm00020a021

Downstream raw materials:

Benzyl-(8-chloro-5-methoxy-3,4-dihydro-naphthalen-2-yl)-amine

(2-Aminomethyl-8-chloro-5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzyl-amine

2-Benzylamino-8-chloro-5-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

Refernces