2,4-Difluorophenylhydrazine

Base Information

• Chemical Name: 2,4-Difluorophenylhydrazine
• CAS No.: 40594-30-7
• Molecular Formula: C6H6F2N2
• Molecular Weight: 144.124
• Hs Code.: 2928000090
• Mol file: 40594-30-7.mol

Synonyms:1-(2,4-Difluorophenyl)hydrazine;

Chemical Property of 2,4-Difluorophenylhydrazine

Chemical Property:

• Vapor Pressure: 0.71mmHg at 25°C
• Melting Point: 65 °C
• Boiling Point: 185.1 °C at 760 mmHg
• PKA: 4.77±0.27(Predicted)
• Flash Point: 65.7 °C
• PSA: 38.05000
• Density: 1.379 g/cm³
• LogP: 2.02370

Purity/Quality:

98% ^*data from raw suppliers

2,4-Difluorophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2,4-difluorophenyl)hydrazine is a reactant in the preparation of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.

Technology Process of 2,4-Difluorophenylhydrazine

There total 2 articles about 2,4-Difluorophenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6) → 2,4-difluorophenylhydrazine (40594-30-7)

Guidance literature:

With sodium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 1.33333h; Product distribution / selectivity;

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → 2,4-difluorophenylhydrazine (40594-30-7)

Guidance literature:

2,4-difluorophenylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃; for 2h;

DOI:10.3390/molecules21111574

Reference yield: 98.0%

2,4-difluorophenylhydrazine (40594-30-7) + 2-acetylcyclopentanaone (1670-46-8) → 2-(2,4-difluorophenyl)-3-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole

Guidance literature:

In neat (no solvent); at 150 ℃; for 0.166667h; regioselective reaction; Microwave irradiation;

DOI:10.1016/j.molstruc.2020.129307

upstream raw materials:

(2,4-difluorophenyl)hydrazinium chloride

2,4-difluorophenylamine

Downstream raw materials:

3-{1-[(2,4-Difluoro-phenyl)-hydrazono]-ethyl}-4-hydroxy-6-methyl-pyran-2-one

3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid N'-(2,4-difluoro-phenyl)-hydrazide

N-(2,4-Difluorphenyl)-N'-thiobenzoylhydrazin

2-Benzoylamino-3-[(2,4-difluoro-phenyl)-hydrazono]-propionic acid ethyl ester

Refernces

• 1、 Wang, Xing,Chen, Yong-Fei,Yan, Wei,Cao, Ling-Ling,Ye, Yong-Hao. "Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi". . . Retrieved 2016/12/03.