3,5-Difluoropyridine

Base Information

• Chemical Name: 3,5-Difluoropyridine
• CAS No.: 71902-33-5
• Molecular Formula: C5H3F2N
• Molecular Weight: 115.082
• Hs Code.: 29333990
• Mol file: 71902-33-5.mol

Synonyms:pyridine,3,5-difluoro

Chemical Property of 3,5-Difluoropyridine

Chemical Property:

• Vapor Pressure: 98.5mmHg at 25°C
• Refractive Index: 1.4437
• Boiling Point: 79.4 °C at 760 mmHg
• PKA: 0.39±0.20(Predicted)
• Flash Point: 1.9 °C
• PSA: 12.89000
• Density: 1.263 g/cm³
• LogP: 1.35980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Difluoropyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,F,N,Xn
• Statements: 36/37/38-50-20/21/22-11
• Safety Statements: 26-36/37/39-61-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Difluoropyridine

There total 4 articles about 3,5-Difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetrafluoropyridine (2875-18-5) → 3-Fluoropyridine (372-47-4) + 2,3,6-trifluoropyridine (3512-18-3) + 2,3,5‐trifluoropyridine (76469-41-5) + 3,5-difluoropyridine (71902-33-5)

Guidance literature:

With triethylsilane; [Rh(μ-H)(1,3-bis(diisopropylphosphanyl)propane)]₂; In benzene-d6; at 50 ℃; for 48h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.jfluchem.2013.05.021

Reference yield:

Pentafluoropyridine (700-16-3) → 3-Fluoropyridine (372-47-4) + 2,3,5,6-tetrafluoropyridine (2875-18-5) + 3,5-difluoropyridine (71902-33-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 28h; Title compound not separated from byproducts;

Reference yield:

Pentafluoropyridine (700-16-3) → 2,3,5,6-tetrafluoropyridine (2875-18-5) + 2,3,5,6-tetrafluoro-4-hydroxypyridine (2693-66-5) + 2,3,5‐trifluoropyridine (76469-41-5) + 3,5-difluoropyridine (71902-33-5)

Guidance literature:

With NiCl₂*3Bpy; 1-n-butyl-3-methylimidazolim bromide; zinc; In water; at 70 ℃; for 7h;

DOI:10.1016/j.tetlet.2010.02.104

upstream raw materials:

Pentafluoropyridine

2,3,5,6-tetrafluoropyridine

3,5-dichloropyridine

Downstream raw materials:

3,5-difluoro-4-trimethylsilanylpyridine

2-chloro-5-(5-fluoropyridin-3-yloxy)benzenamine

3,5-difluoro-4-(tributylstannyl)pyridine

3,5-difluoro-4-phenylpyridine

Refernces

• 1、 Zámostná, Lada,Ahrens, Mike,Braun, Thomas. "Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates". . p. 132 - 142. Retrieved 2013/10/01.
• 2、 Chambers, Richard D.,Hall, Christopher W.,Hutchinson, John,Millar, Ross W.. "Polyhalogenated heterocyclic compounds. Part 42. Fluorinated nitrogen heterocycles with unusual substitution patterns". . p. 1705 - 1713. Retrieved 2007/10/03.