N-Desmethyl Trifluoperazine Dihydrochloride

Base Information

• Chemical Name: N-Desmethyl Trifluoperazine Dihydrochloride
• CAS No.: 2804-16-2
• Molecular Formula: C20H24Cl2F3N3S
• Molecular Weight: 393.476
• Hs Code.: 2934300000
• Mol file: 2804-16-2.mol

Synonyms:Phenothiazine,10-[3-(1-piperazinyl)propyl]-2-(trifluoromethyl)- (6CI,7CI,8CI);10-[3-(1-Piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;Demethyltrifluoperazine;N-Demethyltrifluoperazine;N-Desmethyltrifluoperazine;

Chemical Property of N-Desmethyl Trifluoperazine Dihydrochloride

Chemical Property:

• Appearance/Colour: White Powder
• Vapor Pressure: 1.48E-10mmHg at 25°C
• Melting Point: 123-125°C
• Refractive Index: 1.571
• Boiling Point: 511 °C at 760 mmHg
• PKA: 9.21±0.10(Predicted)
• Flash Point: 262.8 °C
• PSA: 43.81000
• Density: 1.253 g/cm³
• LogP: 6.53910
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly),

Purity/Quality:

99% ^*data from raw suppliers

N-Desmethyltrifluoperazinedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of the antipsychotic drug Trifluoperazine (TFP). Also a metabolite of Fluphenazine

Technology Process of N-Desmethyl Trifluoperazine Dihydrochloride

There total 7 articles about N-Desmethyl Trifluoperazine Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazine-1-carboxylate (1009797-48-1) → SQ 10018 (2804-16-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 79.0%

piperazine (110-85-0) + 10-(3-chloropropyl)-2-trifluoromethylphenothiazine (1675-46-3) → SQ 10018 (2804-16-2)

Guidance literature:

With sodium iodide;

Reference yield: 74.0%

→ SQ 10018 (2804-16-2)

Guidance literature:

With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

upstream raw materials:

piperazine

10-(3-chloropropyl)-2-trifluoromethylphenothiazine

2-(trifluoromethyl)-10H-phenothiazine

1-formyl-4-(3-chloropropyl)piperazine

Downstream raw materials:

10-{3-[4-(2-[1,3]dioxan-2-yl-ethyl)-piperazin-1-yl]-propyl}-2-trifluoromethyl-10H-phenothiazine

4-<3-(2-Trifluormethyl-phenothiazinyl-(10))-propyl>-piperazin-ethylacetat-(1)

fluphenazine-N-mustard

4-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-aniline

Refernces

• 1、 Kang, Seokmin,Lee, Jung Moo,Jeon, Borami,Elkamhawy, Ahmed,Paik, Sora,Hong, Jinpyo,Oh, Soo-Jin,Paek, Sun Ha,Lee, C. Justin,Hassan, Ahmed H.E.,Kang, Sang Soo,Roh, Eun Joo. "Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents". . p. 186 - 198. Retrieved 2018/04/05.
• 2、 Stankovi?,Dimitrijevi?,Kuzmanovi?,Krsti?,Petkovi?. "Voltammetric determination of an antipsychotic agent trifluoperazine at a boron-doped diamond electrode in human urine". . p. 107058 - 107063. Retrieved 2016/01/08.