Ethyl 4-bromomethylcinnamate

Base Information

• Chemical Name: Ethyl 4-bromomethylcinnamate
• CAS No.: 60682-98-6
• Molecular Formula: C12H13BrO2
• Molecular Weight: 269.138
• Hs Code.: 2916399090
• Mol file: 60682-98-6.mol

Synonyms:4-Bromomethylcinnamicacid ethyl ester;Ethyl p-(bromomethyl)cinnamate;Ethyl 4-bromomethylcinnamate;

Chemical Property of Ethyl 4-bromomethylcinnamate

Chemical Property:

• Vapor Pressure: 5.27E-05mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 347.8 °C at 760 mmHg
• Flash Point: 164.1 °C
• PSA: 26.30000
• Density: 1.37 g/cm³
• LogP: 3.15780

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 4-Bromomethylcinnamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 4-bromomethylcinnamate can be used in the preparation of cinnamamide derivative as 5α-reductase inhibitors. Used in the preparation of cinnamamide derivative as 5α-reductase inhibitors.

Technology Process of Ethyl 4-bromomethylcinnamate

There total 2 articles about Ethyl 4-bromomethylcinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

ethyl p-methylcinnamate (20511-20-0) → ethyl p-bromomethylcinnamate (60682-98-6)

Guidance literature:

ethyl p-methylcinnamate; In tetrachloromethane; at 110 ℃; for 1h; under 3040.2 Torr; Inert atmosphere;

With dodecyltrimethylammonium bromide; acetic acid; In tetrachloromethane; at 140 ℃; for 5h; under 5320.36 Torr;

Reference yield:

→ ethyl p-bromomethylcinnamate (60682-98-6)

Guidance literature:

Entspr. Toluol, NBS;

Reference yield:

ethyl p-bromomethylcinnamate (60682-98-6) → ethyl 4-<2-(4-nitrophenyl)ethenyl>cinnamate (58702-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: xylene / 24 h / Heating

2: sodium ethoxide / ethanol

3: ethanol / 168 h / Ambient temperature

With sodium ethanolate; In ethanol; xylene;

upstream raw materials:

ethyl p-methylcinnamate

Downstream raw materials:

4-(2-ethoxycarbonylethenyl)benzyltriphenylphosphonium bromide

ethyl 4-<2-(4-nitrophenyl)ethenyl>cinnamate

ethyl 4-(2-phenylethenyl)cinnamate

ethyl 4-<2-(4-methylphenyl)ethenyl>cinnamate

Refernces

• 1、 -. "6-Membered heterocyclic compound and use thereof". Page/Page column 219. . Retrieved 2008/06/13.