Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate

Base Information

• Chemical Name: Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
• CAS No.: 70254-52-3
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.191
• Hs Code.: 29333990
• Mol file: 70254-52-3.mol

Synonyms:2,4-Dihydroxy-6-methyl-3-pyridinecarboxylic acid ethyl ester

Chemical Property of Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 205oC
• Boiling Point: 363.155ºC at 760 mmHg
• PKA: 8.08±0.28(Predicted)
• Flash Point: 173.43ºC
• PSA: 79.65000
• Density: 1.555g/cm3
• LogP: 0.97790
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl 2,4-dihydroxy-6-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate

There total 2 articles about Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.85%

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) + diethyl malonate (105-53-3) → ethyl 2,4-dihydroxy-6-methylnicotinate (10350-10-4,70254-52-3,70254-53-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 80 - 90 ℃; for 24h; Temperature;

Reference yield:

→ ethyl 2,4-dihydroxy-6-methylnicotinate (10350-10-4,70254-52-3,70254-53-4)

Guidance literature:

3-Amino-crotonsaeure-ethylester, 1.) Malonsaeure-diethylester, 2.) abs. A., Na (110-120grad);

Reference yield: 64.0%

ethyl 2,4-dihydroxy-6-methylnicotinate (10350-10-4,70254-52-3,70254-53-4) + benzyl bromide (100-39-0) → ethyl 2-(benzyloxy)-4-hydroxy-6-methylnicotinate

Guidance literature:

With silver carbonate; In tetrahydrofuran; at 60 ℃; for 12h; Concentration; Solvent;

upstream raw materials:

ethyl aminocrotonate

diethyl malonate

Downstream raw materials:

2,4-dihydroxy-6-methyl-5-(4-nitro-phenylsulfanyl)-nicotinic acid ethyl ester

2,4-dihydroxy-6-methylpyridine

2,4-dichloro-6-methyl-nicotinoyl chloride

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

Refernces