Nalpha-Fmoc-L-lysine hydrochloride

Base Information

• Chemical Name: Nalpha-Fmoc-L-lysine hydrochloride
• CAS No.: 139262-23-0
• Molecular Formula: C₂₁H₂₄N₂O₄*ClH
• Molecular Weight: 404.894
• Hs Code.: 29242990
• Mol file: 139262-23-0.mol

Synonyms:L-Lysine,N²-[(9H-fluoren-9-ylmethoxy)carbonyl]-, monohydrochloride (9CI);Fmoc-Lys-OH HCl;Fmoc-Lys-OH·HCl;

Chemical Property of Nalpha-Fmoc-L-lysine hydrochloride

Chemical Property:

• Vapor Pressure: 1.29E-15mmHg at 25°C
• Refractive Index: -11.0 ° (C=1, DMF)
• Boiling Point: 607.6 °C at 760 mmHg
• Flash Point: 321.3 °C
• PSA: 101.65000
• LogP: 5.00050
• Storage Temp.: 2-8°C
• Solubility.: Soluble in dimethyl formamide (0.3g in 2ml).

Purity/Quality:

≥98.0% ^*data from raw suppliers

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as an active pharmaceutical intermediate and in the synthesis of nε-(7-diethylaminocoumarin-3-carboxyl)- and nε-(7-methoxycoumarin-3-carboxyl)-l-fmoc lysine as tools for protease cleavage detection by fluorescence.

Technology Process of Nalpha-Fmoc-L-lysine hydrochloride

There total 1 articles about Nalpha-Fmoc-L-lysine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-D-Lys(BOC)-OH (92122-45-7) → Fmoc-Lys-OH hydrochloride (201002-47-3,139262-23-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; for 16h;

DOI:10.1039/c7cc08028j

Reference yield: 75.0%

C30H26N2O7 + 9-fluorenylmethoxycarbonyl-L-alanine hydrochloride (139262-23-0) → C47H45N3O8

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 18h;

Reference yield: 70.0%

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione (94142-97-9) + α-Fmoc-L-lysine hydrochloride (139262-23-0) → Fmoc-Lys(Dde)-OH (150629-67-7)

Guidance literature:

α-Fmoc-L-lysine hydrochloride; With N-ethyl-N,N-diisopropylamine; In water; at 20 ℃;

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione; With trifluoroacetic acid; In ethanol; water; for 60h; Reflux;

upstream raw materials:

Fmoc-D-Lys(BOC)-OH

Downstream raw materials:

N_ε-(1-deoxy-fructos-1-yl)-L-lysine

(S)-11-((tert-butoxycarbonyl)amino)-1-(9H-fluoren-9-yl)-15,15-dimethyl-3,13-dioxa-2,14-dioxa-4,10,12-triazahexadecyl-11-ene-5-carboxylic acid

(S)-2-((S)-2-((R)-2-amino-3-phenylpropanamido)-6-(ethanethioamido)hexanamido)propanoic acid

(S)-2-((S)-6-(ethanethioamido)-2-(3-phenylpropanamido)hexanamido)propanoic acid

Refernces