(R)-3-Hydroxypiperidine hydrochloride

Base Information

• Chemical Name: (R)-3-Hydroxypiperidine hydrochloride
• CAS No.: 198976-43-1
• Molecular Formula: C₅H₁₂NO*Cl
• Molecular Weight: 137.609
• Hs Code.: 29339900
• European Community (EC) Number: 626-558-0
• DSSTox Substance ID: DTXSID30941775
• Mol file: 198976-43-1.mol

Synonyms:198976-43-1;(R)-3-Hydroxypiperidine hydrochloride;(R)-piperidin-3-ol hydrochloride;(3R)-piperidin-3-ol hydrochloride;(R)-3-Hydroxypiperidine hydrocloride;(R)-(+)-3-Hydroxypiperidine hydrochloride;(R)-3-Hydroxypiperidine HCl;(R)-3-Hydroxypiperidine, HCl;(3R)-piperidin-3-ol;hydrochloride;3-Piperidinol, hydrochloride, (3R)-;(3R)-3-PIPERIDINOL HYDROCHLORIDE;(r)-3-piperidinol hydrochloride;MFCD00192221;(3R)-3-hydroxypiperidine hydrochloride;SCHEMBL311314;(R)-piperidin-3-olhydrochloride;DTXSID30941775;VLECDMDGMKPUSK-NUBCRITNSA-N;STR09634;(R)-3-hyroxypiperidine hydrochloride;(r)-(+)-3-piperidinol hydrochloride;(R)-piperidin-3-ol hydrogen chloride;AKOS015848381;AKOS015897956;(R)-3-hydroxy piperidine hydrochloride;(R)-3-hydroxy-piperidine hydrochloride;CS-W013330;(3r)-piperidin-3-ol hydrochloride salt;AC-23873;BP-13215;AM20090141;H1537;3-Piperidinol, hydrochloride (1:1), (3R)-;EN300-266117;(R)-(+)-3-Hydroxypiperidine hydrochloride, 98%

Chemical Property of (R)-3-Hydroxypiperidine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.134mmHg at 25°C
• Melting Point: 195-196 °C(lit.)
• Boiling Point: 191.9 °C at 760 mmHg
• Flash Point: 104.5 °C
• PSA: 32.26000
• LogP: 0.86150
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 137.0607417
• Heavy Atom Count: 8
• Complexity: 56

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-3-Hydroxypiperidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/7/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)O.Cl
• Isomeric SMILES: C1C[C@H](CNC1)O.Cl
• Uses: Starter for (R)-(+)-3-pyrrolidyl benzilates with pharmaceutical applications.

Technology Process of (R)-3-Hydroxypiperidine hydrochloride

There total 4 articles about (R)-3-Hydroxypiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate (143900-44-1) → (S)-3-hydroxypiperidine hydrochloride (475058-41-4,198976-43-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; at 20 ℃; for 2h; Temperature; Solvent; Inert atmosphere;

Reference yield:

tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate (924651-55-8) → (S)-3-hydroxypiperidine hydrochloride (475058-41-4,198976-43-1)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 7h;

DOI:10.1016/j.tet.2006.10.073

Reference yield:

3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (924651-53-6) → (S)-3-hydroxypiperidine hydrochloride (475058-41-4,198976-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / hydrogen / PtO₂ / ethyl acetate / 1 h

2: HCl / methanol; H₂O / 7 h / 20 °C

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; water; ethyl acetate;

DOI:10.1016/j.tet.2006.10.073

upstream raw materials:

tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate

3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Downstream raw materials:

N-tert-butoxycarbonyl-3-piperidinol

1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-4-((R)-3-hydroxypiperidin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

3-hydroxy-piperidine-1-carboxylic acid benzyl ester

(R)-5-benzyloxy-2-{2-[4-(3-hydroxy-piperidin-1-ylmethyl)-2-methyl-phenyl]-2-oxo-ethyl}-2H-pyridazin-3-one

Refernces

• 1、 -. "Method for industrially producing (S)-3-(4-bromophenyl) piperidine". Paragraph 0060; 0061; 0065; 0066; 0070; 0071. . Retrieved 2020/02/14.