Imidazo[1,2-a]pyridine-6-boronic acid

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-6-boronic acid
• CAS No.: 913835-63-9
• Molecular Formula: C7H7BN2O2
• Molecular Weight: 161.956
• Hs Code.: 2934100090
• Mol file: 913835-63-9.mol

Synonyms:Boronicacid, imidazo[1,2-a]pyridin-6-yl- (9CI);[Imidazo[1,2-a]pyridin-6-yl]boronicacid;

Chemical Property of Imidazo[1,2-a]pyridine-6-boronic acid

Chemical Property:

• Vapor Pressure: 3.81E-09mmHg at 25°C
• Melting Point: 115-117 °C.
• Refractive Index: 1.671
• Boiling Point: 457°C at 760 mmHg
• PKA: 7.99±0.43(Predicted)
• Flash Point: 230.2°C
• PSA: 57.76000
• Density: 1.31 g/cm³
• LogP: -0.98590
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridine-6-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Imidazo[1,2-a]pyridine-6-boronic acid is a useful intermediate for organic synthesis and other pharmaceutical processes.

Technology Process of Imidazo[1,2-a]pyridine-6-boronic acid

There total 2 articles about Imidazo[1,2-a]pyridine-6-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-bromoimidazo[1,2-a]pyridine (6188-23-4) + bis(pinacol)diborane (73183-34-3) → (imidazo[1,2-a]pyridin-6-yl)boronic acid (913835-63-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium acetate; tricyclohexylphosphine; In 1,4-dioxane; at 115 - 120 ℃; for 24h; Temperature;

Reference yield:

→ (imidazo[1,2-a]pyridin-6-yl)boronic acid (913835-63-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;

Reference yield: 71.7%

(imidazo[1,2-a]pyridin-6-yl)boronic acid (913835-63-9) + 5-bromo-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (84725-13-3) → olprinone (106730-54-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In toluene; at 90 - 100 ℃; for 24h; Temperature; Solvent; Inert atmosphere;

upstream raw materials:

6-bromoimidazo[1,2-a]pyridine

bis(pinacol)diborane

Downstream raw materials:

olprinone

Refernces

• 1、 -. "Substituted thiazole derivative and application thereof". Paragraph 0255-0256; 0300-0304. . Retrieved 2019/02/13.