Methyl 4-aminopyridine-3-carboxylate

Base Information

• Chemical Name: Methyl 4-aminopyridine-3-carboxylate
• CAS No.: 16135-36-7
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 29333990
• Mol file: 16135-36-7.mol

Synonyms:Methyl 4-aminonicotinate;4-Aminopyridine-3-carboxylic acid methyl ester;4-Aminonicotinic acid methyl ester;Nicotinicacid, 4-amino-, methyl ester (6CI,8CI);

Chemical Property of Methyl 4-aminopyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.0023mmHg at 25°C
• Melting Point: 172-174℃
• Refractive Index: 1.57
• Boiling Point: 288.7 °C at 760 mmHg
• PKA: 7.04±0.12(Predicted)
• Flash Point: 128.4 °C
• PSA: 65.21000
• Density: 1.238 g/cm³
• LogP: 1.03160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 4-Aminonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aminopyridine-3-carboxylate

There total 15 articles about Methyl 4-aminopyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

4-tert-butoxycarbonylamino-nicotinic acid methyl ester (280115-84-6) → methyl 4-aminonicotinate (16135-36-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 89.8%

methyl 4-((methoxycarbonyl)amino)nicotinate (1356116-53-4) → methyl 4-aminonicotinate (16135-36-7)

Guidance literature:

With hydrogenchloride; In water; for 0.5h; Reflux;

Reference yield: 87.0%

acetoacetic acid methyl ester (105-45-3) + 3-methyl-5-nitro-4(3H)-pyrimidinone (17758-33-7) → methyl 4-aminonicotinate (16135-36-7)

Guidance literature:

With ammonium acetate; In methanol; for 72h; Heating;

DOI:10.1039/b205510d

upstream raw materials:

4-(acetylamino)nicotinic acid

methyl 4-nitronicotinate 1-oxide

methanol

4-aminonicotinic acid

Downstream raw materials:

4-amino-3-hydroxymethylpyridine

Refernces

• 1、 -. "PYRIDOPYRIMIDINES AND METHODS OF THEIR USE". . . Retrieved 2021/12/28.
• 2、 -. "POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS". Page/Page column 98; 99. . Retrieved 2018/07/29.